DNA measurement--an objective predictor of response to irradiation? A review of 24 squamous cell carcinomas of the oral cavity.
DNA measurement--an objective predictor of response to irradiation? A review of 24 squamous cell carcinomas of the oral cavity.
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DOI：
10.1038/bjc.1986.108
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发表时间：
1986-05
影响因子：
8.8
通讯作者：
Risberg B
中科院分区：
文献类型：
--
作者：
Franzén G;Klintenberg C;Olofsson J;Risberg B
24例口腔鳞状细胞癌术前放疗活检材料的DNA测量结果表明，DNA非整倍体肿瘤对放疗的反应优于二倍体和多倍体肿瘤。术前放疗根除的8例肿瘤的平均S期值（16.1%）高于13例无反应的肿瘤（8.1%）。这些因素与反应的相关性优于组织学和临床（T）分类。DNA倍体和S期估计可以补充组织学诊断，并可能在计划治疗时证明有价值。
DNA measurements on biopsy material from 24 squamous cell carcinomas of the oral cavity given preoperative radiotherapy indicate that DNA aneuploid tumours respond better to radiotherapy than do diploid and polyploid tumours. The mean S-phase value was higher (16.1%) for 8 tumours that were eradicated by preoperative radiotherapy than for 13 that did not respond (8.1%). These factors correlated better with the response than did histological and clinical (T) classifications. DNA-ploidy and S-phase estimation can complement the histological diagnosis, and may prove valuable when planning treatment.