Highly stereo- and regioselective Ni-catalyzed homoallylation of aldimines with conjugated dienes promoted by diethylzinc
Highly stereo- and regioselective Ni-catalyzed homoallylation of aldimines with conjugated dienes promoted by diethylzinc
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DOI：
10.1021/ja0450354
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发表时间：
2004-11-10
影响因子：
15
通讯作者：
Tamaru, Y
中科院分区：
文献类型：
--
作者：
Kimura, M;Miyachi, A;Tamaru, Y
在镍催化下，以二乙基锌为还原剂，一锅法将1，3-二烯、烷基或芳基醛、苯胺三组分连接，得到醛亚胺与二烯的高烯丙基化产物3-取代3，5-顺-5-（芳氨基）-1-烯1，产率高，区域和立体选择性高。
Under the nickel catalysis, in one pot, diethylzinc serves as a reducing agent to connect the three components of 1,3-dienes, alkyl or aryl aldehydes, and anilines to furnish 3-substituted 3,5-syn-5-(arylamino)pent-1-enes1, the homoallylation products of aldimines with dienes, in excellent yields and with high regio- and stereoselectivity.