One-pot β-substitution of enones with alkyl groups to β-alkyl enones
One-pot β-substitution of enones with alkyl groups to β-alkyl enones
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DOI：
10.1039/b502134k
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发表时间：
2005-01-01
影响因子：
4.9
通讯作者：
Aizawa, Y
中科院分区：
文献类型：
--
作者：
Matsuo, J;Aizawa, Y
在一锅法中，通过将高级氰基铜酸二烷基酯共轭加成到烯酮上，然后与N-叔丁基苯亚磺酰亚胺酰氯在-78 ° C下反应，有效地用烷基取代烯酮β-位上的乙烯基氢，以良好至高的分离产率得到β-烷基烯酮。
Vinylic hydrogens at the β-position of enones were effectively substituted with alkyl groups in a one-pot procedure to afford β-alkyl enones in good to high isolated yields by conjugate addition of higher-order dialkyl cyanocuprates to enones, followed by a reaction with N-tert-butylbenzenesulfinimidoyl chloride at -78 ° C.