Quality of life after microvascular mandibular reconstruction for osteoradionecrosis-A prospective study
Quality of life after microvascular mandibular reconstruction for osteoradionecrosis-A prospective study
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DOI：
10.1002/hed.25681
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发表时间：
2019-07-01
影响因子：
2.9
通讯作者：
Halle, Martin
中科院分区：
文献类型：
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作者：
Danielsson, Daniel;Munck-Wikland, Eva;Halle, Martin
背景下颌骨放射性骨坏死的重建手术正在增加，然而，缺乏关于其对健康相关生活质量影响的证据。目前的探索性研究前瞻性地调查了切除重建是否与这些患者的HRQoL参数变化相关。方法2012 - 2015年17例下颌骨放射性骨坏死患者接受微血管重建术，16例患者在术前1个月和术后1年完成EORTC生活质量问卷QLQ-C30和QLQ-H&N35。结果观察到情绪（P = 0.01）和社会功能（P = 0.004）的增加，以及疲劳（P = 0.04），食欲不振（P = 0.02）和疼痛（P = 0.02）评分的改善，由QLQ-C30评价。QLQ-H&N35（P = 0.04）进一步证实了疼痛减轻，这也表明感觉不适（P = 0.001）和性困难（P = 0.04）的评分有所改善。结论下颌骨放射性骨坏死后微血管重建可改善患者的HRQoL，并能减轻疼痛，但仍需进一步研究。
Background Reconstructive surgery for mandibular osteoradionecrosis is increasing; however, evidence regarding the impact on health-related quality of life is lacking. The current exploratory study prospectively investigates whether resection with reconstruction is associated with changes in HRQoL parameters for these patients. Methods Seventeen patients underwent microvascular reconstruction for mandibular osteoradionecrosis between 2012 and 2015, and 16 completed the EORTC quality of life questionnaires QLQ-C30 and QLQ-H&N35 1 month before and 1 year after surgery. Results Increases in emotional (P = 0.01) and social functioning (P = 0.004) were observed, together with improvements in the fatigue (P = 0.04), appetite loss (P = 0.02) and pain (P = 0.02) scores, as evaluated by the QLQ-C30. Pain reduction was further confirmed by the QLQ-H&N35 (P = 0.04), which also showed improved scores for feeling ill (P = 0.001) and sexual difficulties (P = 0.04). Conclusion This exploratory study suggests that microvascular reconstruction after mandibular osteoradionecrosis may improve HRQoL, with an emphasis on pain reduction; however, further studies are needed.