Novel triphosphorylation polyurethane nanoparticles for blood-contacting biomaterials' coating
Novel triphosphorylation polyurethane nanoparticles for blood-contacting biomaterials' coating
复制标题
用于血液接触生物材料涂层的新型三磷酸化聚氨酯纳米颗粒
DOI：
10.1039/c5tb01877c
复制
发表时间：
2016
影响因子：
7
通讯作者：
Shen Jian
中科院分区：
文献类型：
--
作者：
Zhang Jun;Sun Zhijun;Zhu Haomiao;Guo Qiaochu;He Chengai;Xia Ao;Mo Hong;Huang Xiaohua;Shen Jian
改善与人体血液接触的生物材料和装置的血液相容性一直是深入研究的主题。在本研究中，我们合成了一种新型的优良的血液相容性聚氨酯/三聚磷酸钠纳米粒子（PU/STPP）。通过透射电子显微镜（TEM）、扫描电子显微镜（SEM）、动态光散射（DLS）、核磁共振（NMR）和能量色散谱（EDS）对聚氨酯/三聚磷酸钠（PU/STPP）纳米粒子进行了表征。通过体外凝血时间、血浆凝血时间、溶血率和红细胞形态学试验评价PU/STPP纳米粒的血液相容性。通过MTT细胞活力测试获得PU/STPP纳米颗粒的细胞相容性评价。PU/STPP纳米粒子也被用于共沉淀改性人造血管。血小板粘附试验表明，聚氨酯/三聚磷酸钠纳米粒子涂层人造血管的血液相容性优于纯人造血管。
Improving hemocompatibility of biomaterials and devices contacting the human blood has been the subject of intensive research. In this study, we synthesized a novel excellent blood compatible polyurethane/sodium triphosphate nanoparticle (PU/STPP). Characterization of polyurethane/sodium triphosphate (PU/STPP) nanoparticles was carried out by transmission electron microscopy (TEM), scanning electron microscopy (SEM), dynamic light scattering (DLS), nuclear magnetic resonance (NMR), and energy dispersive spectroscopy (EDS). Blood compatibility assessment of PU/STPP nanoparticles was performed by in vitro coagulation time, plasma clotting time, hemolysis rate, and red blood cell morphology tests. Cell compatibility evaluations of PU/STPP nanoparticles were obtained by MTT cell viability tests. The PU/STPP nanoparticles also were used to modify vascular prostheses with cosedimentation. Platelet adhesion tests showed that blood compatibility of vascular prostheses coated with PU/STPP nanoparticles is better than that of pure vascular prostheses.