The perception of respiratory work and effort can be independent of the perception of air hunger
The perception of respiratory work and effort can be independent of the perception of air hunger
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DOI：
10.1164/ajrccm.162.5.9907096
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发表时间：
2000-11-01
影响因子：
24.7
通讯作者：
Banzett, RB
中科院分区：
文献类型：
--
作者：
Lansing, RW;Im, BSH;Banzett, RB
患者的呼吸困难可能由呼吸冲动和呼吸努力增加引起。两种性质不同的感觉，“空气饥饿”和“呼吸工作和努力”，由不同的传入来源引起的假设，在实验室中，低于自发水平的呼吸可能会产生不舒服的空气饥饿感，而高于自发水平的呼吸可能会产生工作或努力的感觉。测量单一的感觉维度无法将这些感觉区分开来，因此我们测量了两个感觉维度，并试图独立地改变它们。在5名正常受试者中，我们同时获得了空气饥饿和工作和努力的评级，同时独立地改变Pco（2）或有针对性的自主呼吸水平。我们发现了对两个刺激维度的反应的差异：当Pco（2）改变而通气量恒定时，空气饥饿评级的变化更急剧;当通气量改变而Pco（2）恒定时，工作或努力评级的变化更急剧。我们的结论是，“空气饥饿”是从“工作和努力”，并从不同的传入来源产生质的不同。
Dyspnea in patients could arise from both an urge to breathe and increased effort of breathing. Two qualitatively different sensations, "air hunger" and "respiratory work and effort," arising from different afferent sources are hypothesized, in the laboratory, breathing below the spontaneous level may produce an uncomfortable sensation of air hunger, and breathing above it a sensation of work or effort. Measurement of a single sensory dimension cannot distinguish these as separate sensations; we therefore measured two sensory dimensions and attempted to vary them independently. In five normal subjects we obtained simultaneous ratings of air hunger and of work and effort while independently varying Pco(2) or the level of targeted voluntary breathing. We found a difference in response to the two stimulus dimensions: air hunger ratings changed more steeply when Pco(2) was altered and ventilation was constant; work or effort ratings changed more steeply when ventilation was altered and Pco(2) was constant. We conclude that "air hunger" is qualitatively different from "work and effort" and arises from different afferent sources.