Mesenchymal target cell specificity of egg granuloma-derived fibroblast growth factor in schistosomiasis.
Mesenchymal target cell specificity of egg granuloma-derived fibroblast growth factor in schistosomiasis.
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血吸虫病中卵肉芽肿衍生的成纤维细胞生长因子的间充质靶细胞特异性。
DOI：
10.1093/infdis/155.4.728
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Libby,P
中科院分区：
文献类型：
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作者：
Wyler,DJ;Prakash,S;Libby,P
我们先前证实，从感染曼氏血吸虫的小鼠肝脏分离的虫卵肉芽肿分泌刺激成纤维细胞增殖的因子。因为这种生长因子也刺激胸腺细胞增殖，我们进一步研究了这种因子的间充质靶细胞特异性。Wenow报道肉芽肿还分泌促进主动脉平滑肌和内皮细胞生长的物质。我们发现，刺激成纤维细胞和平滑肌细胞生长的活性具有相似的物理化学性质（Mr，30-40千道尔顿[kDa]; pI，6.5），这一结果表明它们是相同或相关的分子。相反，最大程度刺激内皮细胞的组分（Mr，<10 kDa; pI，6.7-7.5）对其他两种细胞类型具有最小的影响或没有影响。我们推测可溶性肉芽肿产物也可能刺激血管平滑肌和内皮细胞的增殖，并有助于血吸虫病肝内血管的病理。
We previously demonstrated that egg granulomas isolated from the liver of mice infected withSchistosoma mansonisecrete factors that stimulate fibroblast proliferation in vitro. Because this growth factor also stimulated thymocyte proliferation, we further investigated the mesenchymal target cell specificity of this factor. Wenow report that granulomas also secrete material that promotes growth of aortic smooth muscle and endothelial cells. We found that the activities that stimulate fibroblast and smooth muscle cell growth share similar physicochemical properties (Mr, 30–40 kilodaltons [kDa]; pI, ∼6.5), a result suggesting that they are the same or related molecules. In contrast, fractions (Mr, <10 kDa; pI, 6.7–7.5) that maximally stimulated endothelial cells had minimal or no effects on the other two cell types. We postulate that soluble granuloma products might also stimulate in vivo proliferation of vascular smooth muscle and endothelial cells and contribute to the pathology of the intrahepatic vessels in schistosomiasis.