Hypotensive effects of ovine and human corticotrophin-releasing factors in man
Hypotensive effects of ovine and human corticotrophin-releasing factors in man
复制标题
绵羊和人类促肾上腺皮质激素释放因子对人类的降压作用
DOI：
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发表时间：
2004
影响因子：
2.9
通讯作者：
P. Kloppenborg
中科院分区：
文献类型：
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作者：
A. Hermus;G. Pieters;J. Willemsen;H. Ross;A. Smals;T. Benraad;P. Kloppenborg
本文比较了100 μ g、200 μ g羊肾循环因子和200 μ g人肾循环因子在人体内的血流动力学作用。尽管所有受试者的脉搏率都有所增加，但100µg的绵羊和100µg的人类CRF均未引起血压的显著变化。人CRF后脉搏率平均最大增幅几乎是羊CRF后的两倍（21 vs 12次·min - 1， p<0.05）。所有受试者在给予200µg绵羊CRF后，舒张压逐渐从77 mm Hg下降到22 min时的最低点67 mm Hg （p<0.002）。200µg人CRF后，舒张压在6分钟内从78 mm Hg降至61 mm Hg的最低点（p<0.002）；人CRF后下降率显著高于羊CRF后（p<0.05）。200µg绵羊CRF后，脉搏率略有增加，持续6分钟，200µg人CRF后，有明显的（反射性）心动过速，持续30分钟。只有在服用了最高剂量的人体CRF后，才会出现收缩压的轻微升高。两种剂量的人CRF的血流动力学影响都伴随着血浆去甲肾上腺素浓度的显著增加，且剂量越高，去甲肾上腺素浓度越高。
SummaryThe haemodynamic effects of i.v. bolus injections of 100 and 200 µg ovine CRF and human CRF in man have been compared. Neither ovine CRF 100 µg nor human CRF 100 µg caused a significant change in blood pressure, although the pulse rate was increased in all the subjects tested. The mean maximum increase in pulse rate after human CRF was almost twice that after ovine CRF (21 vs 12 beats·min−1;p<0.05). After 200 µg ovine CRF in all subjects the diastolic blood pressure declined gradually from 77 mm Hg to a nadir of 67 mm Hg at 22 min (p<0.002). After 200 µg human CRF diastolic blood pressure fell from 78 mm Hg to a nadir of 61 mm Hg at 6 min (p<0.002); the fall after human CRF was significantly greater than after ovine CRF (p<0.05). After 200 µg ovine CRF there was a slight increase in pulse rate lasting for 6 min, and after 200 µg human CRF there was a marked (reflex) tachycardia for 30 min. Only after the highest dose of human CRF did a slight increase in systolic blood pressure occur. The haemodynamic effects of both doses of human CRF were accompanied by significant increases in plasma noradrenaline concentrations, which were significantly greater after the higher dose.