HISTOPATHOLOGICAL CHARACTERISTICS AND ESTROGEN-RECEPTOR CONTENT IN PRIMARY BREAST-CARCINOMA
HISTOPATHOLOGICAL CHARACTERISTICS AND ESTROGEN-RECEPTOR CONTENT IN PRIMARY BREAST-CARCINOMA
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DOI：
10.1007/bf00496564
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
PALSHOF, T
中科院分区：
文献类型：
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作者：
RASMUSSEN, BB;ROSE, C;PALSHOF, T
对原发性乳腺癌（159 名患者）进行了组织学检查，包括退行性变的等级、细胞结构、弹性组织的数量以及它们是否源自导管或小叶。研究人员对这些变量与雌激素受体 (ER) 含量（内分泌治疗反应的衡量标准）之间可能存在的相关性进行了研究。在富含弹性组织变性的组中，存在明显的 ER 阳性肿瘤数量较多的趋势。发现 ER 含量和组织学等级之间存在显着相关性，而 ER 含量或退行性变等级和细胞结构之间没有相关性。此外，小叶衍生的肿瘤组的 ER 阳性肿瘤数量明显多于导管衍生的肿瘤组。
Primary breast carcinomas (159 patients) were examined histologically with regard to grade of anaplasia, cellularity, amount of elastic tissue and whether they were of ductal or lobular origin. Possible correlations between these variables and the estrogen receptor (ER)-content [a measure of response to endocrine therapy] were investigated. There was a marked tendency toward a greater number of ER-positive tumors in the group rich in elastosis. A significant correlation between the ER-content and the histological grade was found, whereas there was no correlation between either the ER-content or the grade of anaplasia and the cellularity. Furthermore, the group of tumors that were lobular in derivation had a significantly greater number of ER-positive tumors than the group ductally derived.