Diabetes mellitus and incidence of kidney cancer: a meta-analysis of cohort studies
Diabetes mellitus and incidence of kidney cancer: a meta-analysis of cohort studies
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DOI：
10.1007/s00125-011-2051-6
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发表时间：
2011-05-01
期刊：
影响因子：
8.2
通讯作者：
Wolk, A.
中科院分区：
文献类型：
--
作者：
Larsson, S. C.;Wolk, A.
糖尿病与几个部位的癌症风险增加有关，但它与肾癌的关系尚不清楚。通过检索PubMed(1966年1月至2010年12月)和查阅相关文献的参考文献列表，我们进行了一项系统的综述，用Meta分析来检验糖尿病和肾癌发病率之间的关系。我们纳入了队列研究，报告了糖尿病和肾癌发病率之间的RR估计和95%的可信区间(或计算它们的数据)。使用随机效应模型计算总结RR。9项队列研究符合纳入标准。所有研究的分析表明，与非糖尿病患者相比，糖尿病患者患肾癌的风险在统计学上显著增加(RR 1.42，95%CI 1.06-1.91)。不同研究之间存在异质性(p<；0.001为异质性)。女性的相关性(RR 1.70，95%CI 1.47-1.97)强于男性(RR 1.26，95%CI 1.06-1.49)。将分析限制在调整了体重指数(n=3)或吸烟(n=3)的研究中时，RRS分别为1.12(95%可信区间0.99~1.27)和1.29(95%可信区间1.05~1.58)。这一荟萃分析表明糖尿病与肾癌风险呈正相关。未来的研究应该尝试确定这种联系是否有因果关系。
Diabetes is associated with increased risk of cancer at several sites, but its association with cancer of the kidney is unclear. We performed a systematic review with meta-analysis to examine the association between diabetes and incidence of kidney cancer.Pertinent studies were identified by searching PubMed (from January 1966 to December 2010) and reviewing the reference lists of relevant articles. We included cohort studies reporting RR estimates and 95% CI (or data to calculate them) of the association between diabetes and kidney cancer incidence. Summary RRs were calculated using a random-effects model.Nine cohort studies met the inclusion criteria. Analysis of all studies showed that compared with individuals without diabetes, patients with diabetes had a statistically significant increased risk of kidney cancer (RR 1.42, 95% CI 1.06-1.91). There was heterogeneity among studies (p < 0.001 for heterogeneity). The association was stronger in women (RR 1.70, 95% CI 1.47-1.97) than in men (RR 1.26, 95% CI 1.06-1.49). When restricting the analysis to studies that had adjusted for body mass index (n = 3) or cigarette smoking (n = 3), the RRs were 1.12 (95% CI 0.99-1.27) and 1.29 (95% CI 1.05-1.58), respectively.This meta-analysis indicates a positive association between diabetes and risk of kidney cancer. Future research should attempt to establish whether this association is causal.