Risk factors for coronary heart disease in patients treated for human immunodeficiency virus infection compared with the general population
Risk factors for coronary heart disease in patients treated for human immunodeficiency virus infection compared with the general population
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DOI：
10.1086/375844
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发表时间：
2003-07-15
影响因子：
11.8
通讯作者：
Raffi, F
中科院分区：
文献类型：
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作者：
Savès, M;Chêne, G;Raffi, F
将年龄在35-44岁之间接受人类免疫缺陷病毒1型（HIV-1）感染治疗的患者的心血管疾病危险因素分布与基于人群的队列进行比较。与未感染HIV-1的男性（n=527）相比，接受含蛋白酶底物方案治疗的HIV-1感染男性（n=223）的特征是高血压患病率较低，平均高密度脂蛋白胆固醇水平较低，吸烟患病率较高，平均腰臀比较高，平均甘油三酯水平较高。血浆总胆固醇或低密度胆固醇水平以及糖尿病患病率均无差异。在女性受试者中观察到类似趋势。冠心病的预测风险在HIV-1感染的男性（相对危险度[RR]，1.20）和女性（RR，1.59; P
The distribution of risk factors for cardiovascular disease in patients aged 35-44 years who were treated for human immunodeficiency virus type 1 (HIV-1) infection was compared with that for a population-based cohort. HIV-1-infected men treated with a protease inhibitor-containing regimen (n=223), compared with HIV-1-uninfected men (n=527), were characterized by a lower prevalence of hypertension, a lower mean high-density lipoprotein cholesterol level, a higher prevalence of smoking, a higher mean waist-to-hip ratio, and a higher mean triglyceride level. No difference was found for total plasma or low-density cholesterol levels, nor for the prevalence of diabetes. Similar trends were observed among female subjects. The predicted risk of coronary heart disease was greater among HIV-1-infected men (relative risk [RR], 1.20) and women (RR, 1.59; P