Active chloride secretion in the normal human jejunum.
Active chloride secretion in the normal human jejunum.
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正常人空肠中的活性氯分泌。
DOI：
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发表时间：
1980
影响因子：
15.9
通讯作者：
J. Fordtran
中科院分区：
文献类型：
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作者：
G. Davis;C. S. Santa Ana;S. Morawski;J. Fordtran
为了确定小肠是否正常分泌液体，有必要减少或抑制更大的吸收过程，否则会掩盖这种分泌（如果存在）。为此，我们在正常受试者的空肠中灌注无重碳酸盐溶液，因为已经表明，人体小肠的这一部分的主动吸收依赖于管腔重碳酸盐。我们发现，空肠分泌氯化钠和水时，等渗无碳酸氢盐溶液灌注。进一步的研究表明，钠的分泌是被动的，但氯化物的分泌对电化学梯度和观察到的氯离子流量比不同意的流量比计算的被动氯离子运动。因此，我们得出结论，正常空肠积极分泌氯化物，但这是掩盖了更大的吸收过程时，平衡的电解质溶液灌注。这种活跃的氯化物分泌速率可能是调节正常人体肠道中液体吸收速率的因素之一。
To determine whether the small intestine normally secretes fluid, it would be necessary to reduce or inhibit the greater absorptive processes that would otherwise mask such secretion if present. To do this, we perfused bicarbonate-free solutions in the jejunum of normal subjects, because it has been shown that active absorption from this part of the human small intestine is dependent on luminal bicarbonate. We found that the jejunum did secrete sodium chloride and water when isotonic bicarbonate-free solutions were perfused. Further studies revealed that the sodium secretion was passive, but that chloride was secreted against an electrochemical gradient and that observed chloride flux ratios did not agree with the flux ratios calculated for passive chloride movement. We conclude, therefore, that the normal jejunum actively secretes chloride, but that this is masked by greater absorptive processes when balanced electrolyte solutions are perfused. The rate of this active chloride secretion may be one of the factors that regulate the rate of fluid absorption in the normal human intestine.