Cognitive Subtractions May Not Add Up: The Interaction between Semantic Processing and Response Mode
Cognitive Subtractions May Not Add Up: The Interaction between Semantic Processing and Response Mode
复制标题
认知减法可能不会相加：语义处理和响应模式之间的相互作用
作者：
J. Jennings;A. Mcintosh;S. Kapur;E. Tulving;S. Houle
确定与认知处理相关的大脑活动区域通常依赖于减法范式的使用，该范式基于行为背后的神经过程是加性的前提。如果可加性假设成立，那么无论参与者如何做出反应，与语义处理任务相关的大脑区域都应该是相同的。为了研究这一命题，参与者接受了六次PET扫描，在扫描中，他们做出语义或字母词的判断，以三种不同的模式回答“是”或“否”：鼠标点击，口头反应或沉默的想法。分析显示，在所有三种反应条件下，左下额叶皮层、前扣带回和右小脑中与语义处理相关的局部脑血流量增加。然而，有一个显着的相互作用：最大的增加是在鼠标点击条件下观察到的，最弱的变化与沉默的想法。此外，大脑的其他区域对每种反应模式都有独特的激活。结果表明，不同的大脑区域被招募进行语义处理，这取决于参与者如何组织他们的反应。的加性假设和方法的分析与减法技术结合使用的影响进行了讨论。
Determining the areas of brain activity associated with cognitive processing has typically relied on the use of a subtraction paradigm, which is based on the premise that the neural processes underlying behavior are additive. If the additivity assumption is valid then brain regions associated with a semantic processing task should be the same regardless of how participants make a response. To investigate this proposition, participants underwent six PET scans, in which they made semantic or letter word judgments, responding "yes" or "no" in three different modes: mouse-clicking, spoken response, or silent thought. Analyses showed an increase in regional cerebral blood flow associated with semantic processing in the left inferior frontal cortex, anterior cingulate, and right cerebellum for all three response conditions. However, there was a significant interaction: the greatest increase was observed in the mouse-click condition and the weakest change seen with silent thought. Moreover, other areas of the brain were uniquely activated for each response mode. The results indicate that different areas of the brain were recruited for semantic processing depending on how participants had to organize their responses. Implications for the additivity assumption and methods of analysis to be used in conjunction with the subtraction technique are discussed.
影响因子：
3.7
作者：
Felleman, Daniel J.;Van Essen, David C.
通讯作者：
Van Essen, David C.