Growth and development in children born very low birthweight.
Growth and development in children born very low birthweight.
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DOI：
10.1136/archdischild-2015-309427
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发表时间：
2016-09
期刊：
影响因子：
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通讯作者：
DeBoer MD
中科院分区：
文献类型：
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作者：
Scharf RJ;Stroustrup A;Conaway MR;DeBoer MD
旨在研究极低出生体重（VLBW）儿童从出生到2岁的生长情况与发育结局之间的关系。
运用多变量回归分析，将VLBW儿童的运动和智力发育情况与出生时、9个月和2岁时的人体测量指标进行回归分析。
儿童早期纵向研究——出生队列，这是一项纵向队列社区样本研究，旨在代表全美国出生的儿童。
950名VLBW（<1500克）儿童。
9个月和24个月实际年龄时在贝利量表上的运动和认知得分。
很大比例的儿童生长不良，9个月时（已针对早产进行校正）21.3%的儿童年龄别身长z评分<−2（即发育迟缓），2岁时这一比例为34.2%。与z评分>−2的儿童相比，头围、身长和体重生长不足的儿童在9个月和2岁时贝利运动得分较低的校正优势比（aOR）更高（aOR范围为1.8至3.3，所有p<0.05），而9个月时身长和体重不足可预测贝利认知得分较低（aOR分别为2.0和2.4，均p<0.01），2岁时身长和头围不足也可预测（aOR分别为2.9和2.8，均p<0.05）。
人体测量的生长指标与VLBW儿童当前及未来的神经发育结局相关。虽然仔细测量身长可能是一个特别有用的指标，但所有人体测量指标的不足都是发育迟缓的危险因素。
To examine the relationships between growth (birth to age 2 years) and developmental outcomes in children born with very low birthweight (VLBW). Motor and mental development in children born with VLBW were regressed on anthropometric measurements at birth, 9 months and 2 years using multivariable regression. The Early Childhood Longitudinal Study—Birth Cohort, a longitudinal cohort, community sample, designed to be representative of children born across the USA. 950 children born with VLBW (<1500 g). Motor and cognitive scores on the Bayley Scales at 9 months and 24 months chronological age. A high proportion of children exhibited poor growth, with length-for-age z-scores <−2 (ie, stunting) in 21.3% of children at 9 months (adjusted for prematurity) and 34.2% of children at 2 years. Compared with children having z-scores >−2, children with growth shortfalls in head circumference, length and weight had a higher adjusted OR (aOR) of low Bayley motor scores at 9 months and 2 years (aOR ranging from 1.8 to 3.3, all p<0.05), while low Bayley cognitive scores were predicted by 9-month deficits in length and weight (aOR 2.0 and 2.4, respectively, both p<0.01) and 2-year deficits in length and head circumference (aOR 2.9 and 2.8, both p<0.05). Anthropometric measures of growth were linked to current and future neurodevelopmental outcomes in children born with VLBW. While careful length measures may be a particularly useful marker, deficits in all anthropometric measures were risk factors for developmental delays.