PRE-CONDITIONING WITH LOW-LEVEL LASER (LIGHT) THERAPY: LIGHT BEFORE THE STORM
PRE-CONDITIONING WITH LOW-LEVEL LASER (LIGHT) THERAPY: LIGHT BEFORE THE STORM
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DOI：
10.2203/dose-response.14-032.agrawal
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发表时间：
2014-01-01
期刊：
影响因子：
2.5
通讯作者：
Hamblin, Michael R.
中科院分区：
文献类型：
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作者：
Agrawal, Tanupriya;Gupta, Gaurav K.;Hamblin, Michael R.
通过缺血、高温、低温、高压氧（以及许多其他方式）进行预处理是一个快速发展的研究领域，用于可能出现组织损伤的病理条件。由手术、心脏病发作或中风引起的损伤可以通过用低水平的应激诱导刺激预处理局部或远处组织来减轻，这可以诱导针对随后的重大损伤的保护性反应。近50年来，低强度激光（光）治疗（LLLT）一直用于促进组织愈合，缓解疼痛，炎症和肿胀。光子被细胞色素氧化酶（线粒体呼吸链中的第四单元）吸收，这种酶的激活增加了电子传递、呼吸、氧消耗和ATP的产生。启动复杂的信号级联，导致转录因子的激活和许多基因的上调和下调。最近已经变得明显的是，如果在实际损伤或创伤之前以预处理模式递送至正常细胞或组织，LLLT也可以是有效的。肌肉受到保护，神经感觉不到疼痛，LLLT可以防止随后的心脏病发作。这些例子指出了更广泛地使用LLLT作为预处理方式的方法，以防止疼痛并增加手术/医疗程序后的愈合，并可能提高运动表现。
Pre-conditioning by ischemia, hyperthermia, hypothermia, hyperbaric oxygen (and numerous other modalities) is a rapidly growing area of investigation that is used in pathological conditions where tissue damage may be expected. The damage caused by surgery, heart attack, or stroke can be mitigated by pre-treating the local or distant tissue with low levels of a stress-inducing stimulus, that can induce a protective response against subsequent major damage. Low-level laser (light) therapy (LLLT) has been used for nearly 50 years to enhance tissue healing and to relieve pain, inflammation and swelling. The photons are absorbed in cytochrome(c) oxidase (unit four in the mitochondrial respiratory chain), and this enzyme activation increases electron transport, respiration, oxygen consumption and ATP production. A complex signaling cascade is initiated leading to activation of transcription factors and up- and down-regulation of numerous genes. Recently it has become apparent that LLLT can also be effective if delivered to normal cells or tissue before the actual insult or trauma, in a pre-conditioning mode. Muscles are protected, nerves feel less pain, and LLLT can protect against a subsequent heart attack. These examples point the way to wider use of LLLT as a pre-conditioning modality to prevent pain and increase healing after surgical/medical procedures and possibly to increase athletic performance.