3D LOCALIZED 2D NMR-SPECTROSCOPY ON AN MRI SCANNER
3D LOCALIZED 2D NMR-SPECTROSCOPY ON AN MRI SCANNER
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DOI：
10.1006/jmrb.1995.1068
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发表时间：
1995-05-01
期刊：
影响因子：
--
通讯作者：
THOMAS, MA
中科院分区：
文献类型：
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作者：
RYNER, LN;SORENSON, JA;THOMAS, MA
几种二维核磁共振序列的三维局部化版本已在1.5T全身MRI/MRS扫描仪上实现。除了体素的定位之外，切片选择性RF脉冲还被用于2D核磁共振序列中各种相干的重新聚焦/转移。这里介绍了最初的体模和活体人体研究。这些序列是2D J分辨、2D零量子、2D双量子、零量子过滤COSY和SECSY以及双量子过滤COSY和SECSY的局域版本。对于含有10 mM丙氨酸水溶液的体模，给出了J分辨和多量子序列的二维图。讨论了不同的多量子相干级对B-0不均匀性的敏感性。还提出了包含几种代谢物的生理浓度的体模的局部双量子过滤COSY，以证明在符合人类舒适度的合理时间限制内执行该技术的可行性。本文介绍了首次报道的二维J-分辨活体H-1磁共振波谱，该波谱主要从健康志愿者的脑白质获得，并展示了定位的二维核磁共振技术在体内的应用。(C)1995年学术出版社。
Three-dimensionally localized versions of several two-dimensional NMR sequences have been implemented on a 1.5 T whole-body MRI/MRS scanner. In addition to the localization of voxels, the slice-selective RF pulses were also used for refocusing/transfer of various coherences in the 2D NMR sequences. Initial phantom and in vivo human studies are presented here. The sequences were localized versions of 2D J-resolved, 2D zero-quantum, 2D double-quantum, zero-quantum-filtered COSY and SECSY, and double-quantum-filtered COSY and SECSY. Two-dimensional plots for the J-resolved and multiple-quantum sequences are presented for a phantom containing an aqueous solution of 10 mM alanine. Sensitivity of different multiple-quantum-coherence orders to B-0 inhomogeneity is discussed. Localized double-quantum-filtered COSY of a phantom containing physiological concentrations of several metabolites also is presented to demonstrate the feasibility of performing this technique within time limits reasonable for human comfort. The first-reported 2D J-resolved H-1 in vivo MR spectrum localized in three dimensions in presented here, acquired predominantly from the cerebral white matter of a healthy volunteer and demonstrating the use of localized 2D NMR techniques in vivo. (C) 1995 Academic Press, Inc.