Organ preservation for advanced laryngeal carcinoma
Organ preservation for advanced laryngeal carcinoma
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DOI：
10.1002/hed.20387
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发表时间：
2006-08-01
影响因子：
2.9
通讯作者：
Strome, Scott E.
中科院分区：
文献类型：
--
作者：
Foote, Robert L.;Foote, R. Tyler;Strome, Scott E.
背景资料。将活动声带患者纳入喉保留术试验可能会导致对喉保留率(LPR)和存活率(OS)的夸大。本文是对我们机构中有资格参加退伍军人事务部喉癌研究组(VA)和放射治疗肿瘤组/头颈部间组(RTOG 91-11)临床试验的患者的回顾。有活动声带的患者不能进行喉部保留术。我们机构的101名患者将有资格参加VA试验。全喉切除术和放疗患者的2年OS分别为76%和90%(p=.28)，而VA试验报告的这一比例为68%。我们机构的73名患者将有资格参加RTOG 91-11试验。全喉切除术的5年生存率为52%，放疗患者的5年生存率为63%(p=.18)，而RTOG 91-11试验的5年生存率为55%。放射治疗患者的LPR分别为80%(VA试验)和86%(RTOG 91-11试验)。在VA和RTOG 91-11喉部保留试验中，包括活动声带的患者不太可能对OS或LPR有显著影响。(C)2006年《威利期刊》。Inc.
Background. Inclusion of patients with mobile vocal cords on larynx preservation trials may lead to overstatement of larynx preservation (LPR) and survival (OS) rates.Methods. This is a retrospective review of patients at our institution who would have been eligible for the Department of Veterans Affairs Laryngeal Cancer Study Group (VA) and Radiation Therapy Oncology Group/Head and Neck Intergroup (RTOG 91-11) clinical trials. No laryngeal conservation procedure could be performed in patients with mobile vocal cords.Results. One hundred one patients at our institution would have been eligible for the VA trial. The 2-year OS was 76% for total laryngectomy and 90% for radiotherapy patients (p = .28) compared with 68% reported for the VA trial. Seventy-three patients at our institution would have been eligible for the RTOG 91-11 trial. The 5-year OS was 52% for total laryngectomy and 63% for radiotherapy patients (p = .18) compared with 55% reported for the RTOG 91-11 trial. Radiotherapy patients had an LPR of 80% (VA trial) and 86% (RTOG 91-11 trial).Conclusion. It is unlikely that inclusion of patients with mobile vocal cords had a significant impact on OS or LPR for the VA and RTOG 91-11 larynx preservation trials. (c) 2006 Wiley Periodicals. Inc.