Altered oscillatory alpha and theta networks in schizophrenia
Altered oscillatory alpha and theta networks in schizophrenia
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DOI：
10.1016/j.brainres.2008.06.114
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发表时间：
2008-10-15
期刊：
影响因子：
2.9
通讯作者：
Mathes, B.
中科院分区：
文献类型：
--
作者：
Basar-Eroglu, C.;Schmiedt-Fehr, C.;Mathes, B.
在本研究中，我们使用了一个简单的视觉诱发电位和视觉oddball范式，以调查在不同的频率成分，如α和θ振荡在精神分裂症患者的时间整合的改变。我们发现，无论是刺激发作后的振幅增强，也不是审讯间的相位相干性一般减少患者，但地形的神经反应被改变。虽然健康对照组在后电极部位引起最大早期α和晚期θ反应，但患者的最大反应转移到前电极位置。对于目标的晚期θ反应，未发现该结果，因为在健康对照中，目标处理也伴随着额叶θ振幅增强。地形响应模式的变化反映了两个频带的试验间相位相干性。研究结果表明，精神分裂症与振荡网络的多重改变有关。即使在没有高认知需求的简单任务中，时间和区域协调的功能障碍机制似乎在精神分裂症中也很重要。(c)2008 Elsevier B.V.保留所有权利。
In the present study we used a simple visual evoked potential and a visual oddball paradigm to investigate alterations in the temporal integration of different frequency components such as alpha and theta oscillations in patients with schizophrenia. We found that neither the amplitude enhancement after stimulus onset nor the intertrial phase coherence was generally reduced in patients, but that the topography of the neural response was altered. While healthy controls elicited their maximum early alpha as well as late theta response over posterior electrode sites, the maximum response in patients was shifted to anterior electrode positions. This result was not found for the late theta response for targets as target processing was accompanied with frontal theta amplitude enhancement in healthy controls as well. The change of the topographical response pattern was mirrored by the inter-trial phase coherence in both frequency bands. The findings imply that schizophrenia is related to multiple alterations in oscillatory networks. Even during simple tasks without high cognitive demands dysfunctional mechanisms of temporal and regional coordination appear to be of importance in schizophrenia. (c) 2008 Elsevier B.V. All rights reserved.