Experience with radiofrequency ablation of small hepatocellular carcinomas before liver transplantation
Experience with radiofrequency ablation of small hepatocellular carcinomas before liver transplantation
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DOI：
10.1016/s0041-1345(00)02577-x
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发表时间：
2001-02-01
影响因子：
0.9
通讯作者：
Mazzaferro, V
中科院分区：
文献类型：
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作者：
Pulvirenti, A;Garbagnati, F;Mazzaferro, V
RF和肝移植之间的中位间隔为8个月（范围2至24）。治疗的肿瘤结节的中位直径为35 mm（范围17 - 60）（表1）。RF或奥尔特后均未发生死亡或严重并发症;平均移植后随访16个月（范围1至32）后，所有患者均存活且无肿瘤。关于RF后病理报告，14例患者中的10例（71%）在OLT前放射学和OLT后组织学评估中均具有完全肿瘤坏死。在其他4例（28.5%）中，病理检查时确定肿瘤破坏不完全，所有这些病例在移植前CT扫描时也被列为“治疗不完全”。仅在1例病例（表1中的患者7）中，RF诱导的肿瘤坏死在CT扫描中被广泛低估。
RESULTSMedian interval between RF and liver transplantation was 8 months (range 2 to 24). Median diameter of the treated tumor nodules was 35 mm (range 17 to 60)(Table 1). No deaths or major complications occurred following either RF or OLT; after a mean posttransplant follow-up of 16 months (range 1 to 32), all patients are alive and tumor free. With respect to post-RF pathology reports, 10 of 14 patients (71%) had a complete tumor necrosis on both pre-OLT radiologic and post-OLT histologic evaluation. In the other four cases (28.5%), incomplete tumor destructions were determined at pathology examination, with all those cases ranked as “incompletely treated” also at pretransplant CT scan. In only one case (patient 7 in Table 1) the tumor necrosis induced by RF was widely underestimated at the CT scan.