Assessing TMS-induced D and I waves with spinal H-reflexes.
Assessing TMS-induced D and I waves with spinal H-reflexes.
复制标题
使用脊髓 H 反射评估 TMS 诱导的 D 波和 I 波
DOI:
10.1152/jn.00671.2017
复制
发表时间:
2018
影响因子:
2.5
通讯作者:
Leukel C
中科院分区:
文献类型:
--
作者:
Niemann N;Wiegel P;Kurz A;Rothwell JC;Leukel C
Transcranial magnetic stimulation (TMS) of motor cortex produces a series of descending volleys known as D (direct) and I (indirect) waves. In the present study, we questioned whether spinal H-reflexes can be used to dissect D waves and early and late I waves from TMS. We therefore probed H-reflex facilitation at arrival times of D and I waves at the spinal level and thereby changed TMS parameters that have previously been shown to have selective effects on evoked D and different I waves. We changed TMS intensity and current direction and applied a double-pulse paradigm known as short-interval intracortical inhibition (SICI). Experiments were conducted in flexor carpi radialis (FCR) in the arm and soleus (SOL) in the leg. There were two major findings:1) in FCR, H-reflex facilitation showed characteristic modulations with altered TMS parameters that correspond to the changes of evoked D and I waves; and2) H-reflexes in SOL did not, possibly because of increased interference from other spinal circuits. Therefore, the most significant outcome of this study is that in FCR, H-reflexes combined with TMS seem to be a useful technique to dissect TMS-induced D and I waves.NEW & NOTEWORTHYQuestions that relate to corticospinal function in pathophysiology and movement control demand sophisticated techniques to provide information about corticospinal mechanisms. We introduce a noninvasive electrophysiological technique that may be useful in describing such mechanisms in more detail by dissecting D and I waves from transcranial magnetic stimulation (TMS). Based on the combination of spinal H-reflexes and TMS in the flexor carpi radialis muscle, the technique was shown to measure selective effects on D and I waves from changing TMS parameters.
登录
查看更多内容
影响因子:
5.5
作者:
COWAN, JMA;DAY, BL;ROTHWELL, JC
通讯作者:
ROTHWELL, JC
DOI:
10.1113/jphysiol.2002.021683
发表时间:
2002
期刊:
The Journal of Physiology
影响因子:
--
作者:
V. Marchand;G. Nicolas;D. Burke;E. Pierrot‐Deseilligny
通讯作者:
E. Pierrot‐Deseilligny
影响因子:
5.5
作者:
NIELSEN, J;PETERSEN, N;BALLEGAARD, M
通讯作者:
BALLEGAARD, M
影响因子:
3.7
作者:
W. Taube;J. Lundbye;M. Schubert;A. Gollhofer;Christian Leukel
通讯作者:
Christian Leukel
影响因子:
2
作者:
V. Lazzaro;A. Oliviero;P. Mazzone;A. Insola;F. Pilato;E. Saturno;A. Accurso;P. Tonali;J. Rothwell
通讯作者:
J. Rothwell