In vitro skin retention and drug permeation study of Tongluo-Qutong rubber plaster by UPLC/UV/MS/MS
In vitro skin retention and drug permeation study of Tongluo-Qutong rubber plaster by UPLC/UV/MS/MS
复制标题
UPLC/UV/MS/MS法研究通络祛通胶膏的体外皮肤保留和药物渗透
DOI：
10.1590/s2175-9790202100032e181127
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发表时间：
2022
影响因子：
1.3
通讯作者：
Ying Zhang;Jiaxin Pi;Wen Li;Ludan Zhang;Xutong Ma;D. Kebebe;Dongli Qi;Nan Li;Pan Guo
中科院分区：
文献类型：
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作者：
Ying Zhang;Jiaxin Pi;Wen Li;Ludan Zhang;Xutong Ma;D. Kebebe;Dongli Qi;Nan Li;Pan Guo
近年来，中医（TCM）在关节疼痛的治疗中发挥了重要作用（Lao等人，2015年）。等，2016）。因子-A）（Hennekens等，2014），TCM中广泛使用的天然植物产品可以通过多种组件，靶标和动作来执行协同的治疗效果，从而减少严重的不良副作用和毒性的事件（Wu等人。 ，2015年）。 （委员会，2015年），并于2000年在中国获得临床用途（Z20000065国家药物批准）。疼痛。TQRP包含13个不同的TCM（Angelicae Senensis radix，Chuanxiong Rhizoma，Carthami Flos，Kaempferiae *通信：J。PI *。刘*。 @163.com巴西制药科学杂志
In recent years, traditional Chinese medicine (TCM) has played an important role in the treatment of joint pain (Lao et al., 2015). It has been reported that TCM showed clear effects in acute gouty arthritis and protection of cartilage matrix (Shi et al., 2016). In the treatment of rheumatoid arthritis, unlike western medicines that contain non-steroidal anti-inflammatory drugs (NSAIDS) and biological agents (such as antitumor necrosis factor-a) (Hennekens et al., 2014), the widely used natural plant products in TCM can exert synergistic therapeutic effects through multiple components, targets and actions, thus reducing the incidence of serious adverse side effects and toxicity (Wu et al., 2015). Tongluo-Qutong rubber plaster (TQRP), a typical Chinese patent medicine, is recorded in the Pharmacopoeia of The People’s Republic of China 2015 edition (Committee, 2015) and was authorized for clinical use in China in 2000 (National Drug Approval No. Z20000065). In the theory of traditional Chinese medicine, it has the functions of promoting blood circulation, clearing cold and dehumidifying, reducing swelling and relieving pain. TQRP contains 13 different TCM (Angelicae Sinensis Radix, Chuanxiong Rhizoma, Carthami Flos, Kaempferiae *Correspondence: J. Pi*. Z. Liu*. The Institute of Traditional Chinese Medicine. Tianjin University of Traditional Chinese Medicine. No. 10 Poyanghu Road, Jinghai District, Tianjin 301617, China. Phone: 15510839840 and 13752581592. E-mail: pijiaxin@tjutcm.edu.cn and lonerliuzd@163.com Brazilian Journal of Pharmaceutical Sciences