Stereogenic-Only-at-Metal Asymmetric Catalysts.
Stereogenic-Only-at-Metal Asymmetric Catalysts.
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DOI：
10.1002/asia.201700739
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Lilu Zhang;E. Meggers
中科院分区：
文献类型：
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作者：
Lilu Zhang;E. Meggers
手性是不对称催化剂的基本特征。本文综述了不对称催化剂的手性完全来自立体金属中心。已报道的手性金属催化剂可以分为两类，即惰性金属络合物和反应性金属络合物，在惰性金属络合物中，金属履行纯粹的结构作用，因此催化完全通过配体球介导。后者是特别有吸引力的，因为结构简单（仅非手性配体）与特别有效的不对称诱导（底物与手性金属中心的直接接触）的前景相结合。设计这种反应性的立体仅在金属不对称催化剂的挑战和解决方案进行了讨论。
Chirality is an essential feature of asymmetric catalysts. This review summarizes asymmetric catalysts that derive their chirality exclusively from stereogenic metal centers. Reported chiral-at-metal catalysts can be divided into two classes, namely, inert metal complexes, in which the metal fulfills a purely structural role, so catalysis is mediated entirely through the ligand sphere, and reactive metal complexes. The latter are particularly appealing because structural simplicity (only achiral ligands) is combined with the prospect of particularly effective asymmetric induction (direct contact of the substrate with the chiral metal center). Challenges and solutions for the design of such reactive stereogenic-only-at-metal asymmetric catalysts are discussed.