A MODEL SYSTEM FOR ANALYSIS OF FAMILY RESEMBLANCE IN EXTENDED KINSHIPS OF TWINS
A MODEL SYSTEM FOR ANALYSIS OF FAMILY RESEMBLANCE IN EXTENDED KINSHIPS OF TWINS
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DOI：
10.1007/bf01067927
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发表时间：
1994-01-01
影响因子：
2.6
通讯作者：
KENDLER, KS
中科院分区：
文献类型：
--
作者：
TRUETT, KR;EAVES, LJ;KENDLER, KS
“弗吉尼亚3万人”包括来自5670对双胞胎扩展亲属关系的29698名受试者。从这些亲属关系中可以得出亲属之间超过80种独特的相关性，包括同卵双胞胎（MZ）和异卵双胞胎（DZ）及其配偶、父母、兄弟姐妹和子女。本文描述了一个相当一般的家庭相似性模型的第一个应用，该模型来自弗吉尼亚30,000人的数据。该模型评估了在垂直文化遗传、表型分类交配、共享双胞胎和兄弟姐妹环境以及家庭内部环境存在的情况下，加性和显性遗传效应的贡献。基因和环境的影响取决于性别。配种和文化遗传既可以基于测量的表型，也可以基于测量的表型是不可靠指标的潜在性状。该模型应用于本研究的教会出席率数据。结果表明，基因、垂直文化遗传和基因型-环境协方差的贡献都很重要，但它们的贡献在性别上存在显著异质性。表型分类交配对家庭相似性在教堂出席有重大影响。
The ''Virginia 30,000'' comprise 29,698 subjects from the extended kinships of 5670 twin pairs. Over 80 unique correlations between relatives can be derived from these kinships, comprised of monozygotic (MZ) and dizygotic (DZ) twins and their spouses, parents, siblings, and children. This paper describes the first application of a fairly general model for family resemblance to data from the Virginia 30,000. The model assesses the contributions of additive and dominant genetic effects in the presence of vertical cultural inheritance, phenotypic assortative mating, shared twin and sibling environments, and within-family environment. The genetic and environmental effects can be dependent on sex. Assortment and cultural inheritance may be based either on the phenotype as measured or on a latent trait of which the measured phenotype is an unreliable index. The model was applied to church attendance data from this study. The results show that the contributions of genes, vertical cultural inheritance, and genotype-environment covariance are all important, but their contributions are significantly heterogeneous over sexes. Phenotypic assortative mating has a major impact on family resemblance in church attendance.