Scalable simulation of realistic volume fraction red blood cell flows through vascular networks
Scalable simulation of realistic volume fraction red blood cell flows through vascular networks
复制标题
DOI：
10.1145/3295500.3356203
复制
发表时间：
2019-09
期刊：
影响因子：
--
通讯作者：
Libin Lu;Matthew J. Morse;Abtin Rahimian;G. Stadler;D. Zorin
中科院分区：
文献类型：
--
作者：
Libin Lu;Matthew J. Morse;Abtin Rahimian;G. Stadler;D. Zorin
高分辨率的血流模拟有可能在微观尺度上更好地理解生物物理现象，如血管舒张，血管收缩和整体血管阻力。为此，我们提出了一个可扩展的平台，用于模拟红细胞（RBC）通过复杂的毛细血管流动，通过将物理系统建模为具有浸没的可变形颗粒的粘性流体。我们描述了一个并行边界积分方程求解一般椭圆型偏微分方程，我们适用于斯托克斯流通过血管。我们还详细介绍了一种并行碰撞避免算法，以确保红细胞和血管保持无接触。我们已将德克萨斯州高级计算中心Stampede 2上的代码扩展到34，816个核心。我们最大的模拟在40亿个表面元素之间强制执行无接触状态，并在100万个RBC和由200万个贴片组成的血管上解决了30亿个自由度。
High-resolution blood flow simulations have potential for developing better understanding biophysical phenomena at the microscale, such as vasodilation, vasoconstriction and overall vascular resistance. To this end, we present a scalable platform for the simulation of red blood cell (RBC) flows through complex capillaries by modeling the physical system as a viscous fluid with immersed deformable particles. We describe a parallel boundary integral equation solver for general elliptic partial differential equations, which we apply to Stokes flow through blood vessels. We also detail a parallel collision avoiding algorithm to ensure RBCs and the blood vessel remain contact-free. We have scaled our code on Stampede2 at the Texas Advanced Computing Center up to 34,816 cores. Our largest simulation enforces a contact-free state between four billion surface elements and solves for three billion degrees of freedom on one million RBCs and a blood vessel composed from two million patches.