Palladium-catalysed ring-opening [3+2]-annulation of spirovinylcyclopropyl oxindole to diastereoselectively access spirooxindoles
Palladium-catalysed ring-opening [3+2]-annulation of spirovinylcyclopropyl oxindole to diastereoselectively access spirooxindoles
复制标题
钯催化螺乙烯基环丙基羟吲哚的开环[3 2]-环化非对映选择性地获得螺吲哚
DOI：
10.1039/c8ob02859a
复制
发表时间：
2019-01-07
影响因子：
3.2
通讯作者：
Yang, Hua
中科院分区：
文献类型：
--
作者：
Xiao, Jun-An;Cheng, Xiu-Liang;Yang, Hua
报道了钯催化的螺乙烯基环丙基羟吲哚与，-不饱和硝基烯烃的[3 + 2]-开环成环反应。合成了一系列具有良好非对映选择性的螺吲哚衍生物。该方法为螺羟吲哚的组装提供了一种新的有效途径。
A novel palladium-catalysed ring-opening [3 + 2]-annulation of spirovinylcyclopropyl oxindole with ,-unsaturated nitroalkenes is reported. A series of spirooxindole derivatives were synthesized in high yields and good to excellent diastereoselectivities. This developed protocol offers a new and efficient pathway for the assembly of spirooxindoles.