Clustering of heading selectivity and perception-related activity in the ventral intraparietal area.
Clustering of heading selectivity and perception-related activity in the ventral intraparietal area.
复制标题
DOI：
10.1152/jn.00556.2017
复制
发表时间：
2018-03
影响因子：
2.5
通讯作者：
Mengmeng Shao;G. DeAngelis;D. Angelaki;Aihua Chen
中科院分区：
文献类型：
--
作者：
Mengmeng Shao;G. DeAngelis;D. Angelaki;Aihua Chen
猕猴脑腹侧顶内区（VIP）是一个多模态皮质区，许多细胞都调谐到光流和前庭刺激。许多VIP神经元的反应也表现出强大的相关性与知觉判断在一个精细的标题歧视任务。先前的研究表明，基于光流的航向调整在VIP中以聚类的方式表示。然而，目前尚不清楚前庭自我运动选择性是否聚集在VIP中。此外，目前还不知道是否刺激和选择相关的信号在VIP显示集群的上下文中的标题歧视任务。为了解决这些问题，我们比较了孤立的单单位（SU）的响应特性与未分化的多单位（MU）活动对应的几个相邻的神经元记录从同一个微电极。我们发现，MU活动通常表现出类似的选择性，同时记录SU，前庭和视觉刺激条件。此外，如使用选择概率量化的MU信号的选择相关活动与SU的选择相关活动相关。总的来说，这些发现表明，关于自我运动的感觉和选择相关信号都聚集在VIP中。新&值得注意的是，我们证明，第一次，前庭调谐腹顶内区（VIP）神经元的平移和旋转运动的反应是集群。此外，标题辨别力和选择相关的活动也弱聚在VIP。
The ventral intraparietal area (VIP) of the macaque brain is a multimodal cortical region, with many cells tuned to both optic flow and vestibular stimuli. Responses of many VIP neurons also show robust correlations with perceptual judgments during a fine heading discrimination task. Previous studies have shown that heading tuning based on optic flow is represented in a clustered fashion in VIP. However, it is unknown whether vestibular self-motion selectivity is clustered in VIP. Moreover, it is not known whether stimulus- and choice-related signals in VIP show clustering in the context of a heading discrimination task. To address these issues, we compared the response characteristics of isolated single units (SUs) with those of the undifferentiated multiunit (MU) activity corresponding to several neighboring neurons recorded from the same microelectrode. We find that MU activity typically shows selectivity similar to that of simultaneously recorded SUs, for both the vestibular and visual stimulus conditions. In addition, the choice-related activity of MU signals, as quantified using choice probabilities, is correlated with the choice-related activity of SUs. Overall, these findings suggest that both sensory and choice-related signals regarding self-motion are clustered in VIP. NEW & NOTEWORTHY We demonstrate, for the first time, that the vestibular tuning of ventral intraparietal area (VIP) neurons in response to both translational and rotational motion is clustered. In addition, heading discriminability and choice-related activity are also weakly clustered in VIP.