Supramolecular polymorphism: tunable electronic interactions within π-conjugated peptide nanostructures dictated by primary amino acid sequence.
Supramolecular polymorphism: tunable electronic interactions within π-conjugated peptide nanostructures dictated by primary amino acid sequence.
复制标题
超分子多态性：π-共轭肽纳米结构内可调节的电子相互作用，由一级氨基酸序列决定。
作者：
Brian D. Wall;Ashley E Zacca;Allix M. S. Sanders;William L Wilson;Andrew L Ferguson;J. Tovar
我们提出了一个系统的研究一维电子离域纳米结构组装的π共轭亚基嵌入寡肽骨架的电子物理性质。这些纳米结构内的激发态的性质研究作为一个功能的主要氨基酸序列，利用稳态和时间分辨光谱，和它们的原子结构探测分子模拟。在沿着分子肽骨架的特定残基位置处引入氨基酸侧链的变化导致纤维状结构的观察到的生物物理行为（跨越H样激子偶联和无序准异构体偶联）的显著变化，这是由它们内的π-堆叠的细微变化引起的。这些结果表明，残基修饰-在相对大小，溶剂化性质，并相对于从中央π-电子核心的距离-使能够调整生色团包装和由此产生的超分子组装体的π共轭生物电子材料的物理学的能力，在一个合理的和系统的方式。
We present a systematic study of the photophysical properties of one-dimensional electronically delocalized nanostructures assembled from π-conjugated subunits embedded within oligopeptide backbones. The nature of the excited states within these nanostructures is studied as a function of primary amino acid sequence utilizing steady-state and time-resolved spectroscopies, and their atomistic structure is probed by molecular simulation. Variations introduced into the amino acid side chains at specific residue locations along the molecular peptide backbone lead to pronounced changes in the observed photophysical behavior of the fibrillar structures (spanning H-like excitonic coupling and disordered excimeric coupling) that arise from subtle changes in the π-stacking within them. These results indicate that residue modification-in terms of relative size, solvation properties, and with respect to the distance from the central π-electron core-enables the ability to tune chromophore packing and the resulting photophysics of supramolecular assemblies of π-conjugated bioelectronic materials in a rational and systematic manner.
影响因子：
6.2
作者：
Mu, Xiaojia;Eckes, Kevin M.;Nguyen, Mary M.;Suggs, Laura J.;Ren, Pengyu
通讯作者：
Ren, Pengyu