Riluzole blocks perioperative ischemia-reperfusion injury and enhances postdecompression outcomes in cervical spondylotic myelopathy
Riluzole blocks perioperative ischemia-reperfusion injury and enhances postdecompression outcomes in cervical spondylotic myelopathy
复制标题
DOI：
10.1126/scitranslmed.aac6524
复制
发表时间：
2015-12-02
影响因子：
17.1
通讯作者：
Fehlings, Michael G.
中科院分区：
文献类型：
--
作者：
Karadimas, Spyridon K.;Laliberte, Alex M.;Fehlings, Michael G.
尽管手术减压被认为是脊髓型颈椎病 (CSM) 的金标准治疗方法，但仍有一部分病例术后病情出现下降或继续表现出严重的神经功能障碍。为了进一步调查这一点，我们首先检查了前瞻性多中心 AOSpine 北美 CSM 研究的数据，发现 9.3% 的患者出现术后功能下降（Delta mJOA，
Although surgical decompression is considered the gold standard treatment for cervical spondylotic myelopathy (CSM), a proportion of cases show postoperative decline or continue to exhibit substantial neurological dysfunction. To investigate this further, we first examined data from the prospective multicenter AOSpine North America CSM study, finding that 9.3% of patients exhibited postoperative functional decline (Delta mJOA,