Benzyl protection of phenols under neutral conditions: Palladium-catalyzed benzylations of phenols
Benzyl protection of phenols under neutral conditions: Palladium-catalyzed benzylations of phenols
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DOI：
10.1021/ol800548t
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发表时间：
2008-05-15
期刊：
影响因子：
5.2
通讯作者：
Kusano, Hiroki
中科院分区：
文献类型：
--
作者：
Kuwano, Ryoichi;Kusano, Hiroki
采用Pd(eta(3)-C(3)H(5))Cp-DPEphos催化剂，实现了苯酚在中性条件下的苯保护。钯催化剂通过脱羧醚化反应有效地将芳基碳酸苄酯转化为苯基保护酚。或者，用酚类取代碳酸苄甲酯的亲核取代。在催化剂的存在下进行，得到芳基苄基醚。
Benzyl protection of phenols under neutral conditions was achieved by using a Pd(eta(3)-C(3)H(5))Cp-DPEphos catalyst. The palladium catalyst efficiently converted aryl benzyl carbonates into benzyl-protected phenols through the decarboxylative etherification. Alternatively, the nucleophilic substitution of benzyl methyl carbonates with phenols. proceeded in the presence of the catalyst, yielding aryl benzyl ethers.