Does possession of apolipoprotein E ε4 benefit cognitive function in healthy young adults?
Does possession of apolipoprotein E ε4 benefit cognitive function in healthy young adults?
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DOI：
10.1016/j.neuropsychologia.2011.02.042
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发表时间：
2011-06-01
期刊：
影响因子：
2.6
通讯作者：
Easteal, Simon
中科院分区：
文献类型：
--
作者：
Bunce, David;Anstey, Kaarin J.;Easteal, Simon
有大量证据表明，载脂蛋白 E (APOE) epsilon 4 等位基因与老年人的认知缺陷有关，并且是痴呆症的危险因素。然而，最近有人提出，拥有 epsilon 4 等位基因可能有利于成年早期的认知。我们使用一套全面的认知测量方法，在 5445 名年龄在 20-24 岁、40-44 岁和 60-64 岁之间的社区居民中测试了这种可能性。由于 APOE epsilon 2 等位基因可能提供针对认知缺陷的保护，为了有力地检验该假设，我们从分析中删除了携带该等位基因的人。可能患有痴呆症的老年人也被带走。我们没有发现年轻 epsilon 4 携带者认知能力较高的证据，或老年 epsilon 4 携带者认知缺陷的证据。当考虑一系列健康变量时，这一点并没有改变。我们的结论是，假设 epsilon 4 相关的对健康年轻成年认知的益处还为时过早，与该假设一致的发现可能与方法学问题或所调查样本的病理学有关。 (C) 2011 Elsevier Ltd. 保留所有权利。
There is considerable evidence that the apolipoprotein E (APOE) epsilon 4 allele is associated with cognitive deficits in older persons, and is a risk factor for dementia. However, it has recently been suggested that possession of the epsilon 4 allele may benefit cognition in early adulthood. We tested this possibility in 5445 community-dwelling persons aged 20-24,40-44, and 60-64 years using a comprehensive battery of cognitive measures. As the APOE epsilon 2 allele may offer protection against cognitive deficits, in order to robustly test the hypothesis, we removed persons carrying this allele from the analyses. Older persons with possible dementia were also removed. We found no evidence of higher cognitive performance in young epsilon 4 carriers, or cognitive deficits in older epsilon 4 carriers. This did not change when a range of health variables were taken into account. We conclude that it is premature to suppose epsilon 4-related benefits to cognition in healthy young adulthood and findings consistent with this hypothesis may have been related to methodological issues, or the pathology of the sample investigated. (C) 2011 Elsevier Ltd. All rights reserved.