Glomerular proliferation during early stages of diabetic nephropathy is associated with local increase of sphingosine-1-phosphate levels
Glomerular proliferation during early stages of diabetic nephropathy is associated with local increase of sphingosine-1-phosphate levels
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DOI：
10.1016/j.febslet.2004.12.094
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发表时间：
2005-02-14
期刊：
影响因子：
3.5
通讯作者：
El Bawab, S
中科院分区：
文献类型：
--
作者：
Geoffroy, K;Troncy, L;El Bawab, S
在这项研究中，短期糖尿病（4天）对大鼠肾小球细胞增殖的影响和鞘脂在这一过程中的潜在参与进行了研究。免疫组化分析显示，链脲佐菌素（STZ）诱导的糖尿病促进肾小球内增生，尤其是肾小球系膜细胞。这与中性神经酰胺酶和鞘氨醇激酶活性的伴随增加以及促增殖鞘脂鞘氨醇-1-磷酸的积累有关，肾小球分离自STZ处理的大鼠的肾皮质。这些结果表明，在糖尿病肾病的早期阶段，鞘脂代谢产物可能参与肾小球增殖反应。(C)2005年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
In this study, the effects of short-term diabetes (4 days) on rat renal glomerular cells proliferation and the potential involvement of sphingolipids in this process were investigated. Immunohistochemical analysis showed that streptozotocin (STZ)-induced diabetes promoted increased intra-glomerular hyperplasia, particularly marked for mesangial cells. This was associated with a concomitant increase in neutral ceramidase and sphingosine-kinase activities and the accumulation of the pro-proliferative sphingolipid sphingosine-1-phosphate, in glomeruli isolated from kidney cortex of STZ-treated rats. These results suggest a possible involvement of sphingolipid metabolites in the glomerular proliferative response during the early stages of diabetic nephropathy. (C) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.