Investigations of Host–Guest Interactions with Shape-Persistent Nonionic Dendritic Micelles
Investigations of Host–Guest Interactions with Shape-Persistent Nonionic Dendritic Micelles
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DOI：
10.1021/jp401503y
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发表时间：
2013-05
影响因子：
3.7
通讯作者：
R. Tyagi;S. Malhotra;A. Thünemann;A. Sedighi;Marcus Weber;Andreas Schäfer;R. Haag
中科院分区：
文献类型：
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作者：
R. Tyagi;S. Malhotra;A. Thünemann;A. Sedighi;Marcus Weber;Andreas Schäfer;R. Haag
自组装树枝状两亲物与药物和染料在水溶液中的相互作用对于设计和优化形状持久的递送系统具有重要意义。在这里，我们对作为主体分子的低分子量（LMW）非离子树枝状两亲物和一系列选定的芳香客体模型分子（苯、萘、联苯、三联苯、蒽和芘）的两个例子进行了更深入的了解。将芳香族客体分子纳入树枝状纳米载体的自组装体中，并通过结合紫外、核磁共振、计算模拟和小角X射线散射（SAXS）技术研究所得复合物，以确定树枝状两亲物与客体分子的负载能力、定位和特异性相互作用。我们的研究结果表明，客体分子在疏水区域的定位和客体分子的负载能力取决于它们的大小和芳环的排列，而不是......
The interaction of self-assembled dendritic amphiphiles with drugs and dyes in aqueous solutions is of great significance for designing and optimizing shape-persistent delivery systems. Here we present deeper insight for two examples of low molecular weight (LMW) nonionic dendritic amphiphiles as host molecules and a series of selected aromatic guest model molecules (benzene, naphthalene, biphenyl, terphenyl, anthracene, and pyrene). Aromatic guest molecules were incorporated into the self-assemblies of dendritic nanocarriers, and the resultant complexes were studied by a combination of UV, NMR, computational simulation, and small-angle X-ray-scattering (SAXS) techniques in order to determine the loading capacity, localization, and specific interactions in dendritic amphiphiles with guest molecules. Our findings revealed that the localization of guest molecules in the hydrophobic region and the loading capacity of guest molecules are dependent on their size and the arrangement of aromatic rings instead of...