Diffusion-weighted MRI for evaluation of acute stroke
Diffusion-weighted MRI for evaluation of acute stroke
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DOI：
10.1212/wnl.51.3_suppl_3.s47
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发表时间：
1998-09-01
期刊：
影响因子：
9.9
通讯作者：
Albers, GW
中科院分区：
文献类型：
--
作者：
Albers, GW
扩散加权成像（diffusion weighted imaging， DWI）是一种新的磁共振成像技术，用于检测组织中水分子的微小随机运动（扩散）。该技术允许计算平均表观扩散系数（ADC）的图。缺血性脑卒中发生后，由于细胞毒性水肿，脑组织ADC明显降低。几天后，ADC开始迅速下降，然后在大约1周后恢复到“伪正常”值。随后，ADC值在慢性时间点升高。DWI在检测和定位急性缺血性脑损伤方面非常敏感，可以区分急性缺血和慢性梗死区域。最近的研究表明，早期DWI病变的体积与临床神经预后之间存在高度相关性。此外，早期DWI病变的体积与t2加权成像测量的最终梗死体积有很好的相关性。因此，这项技术可能有助于对中风新药物治疗的患者进行最佳选择，并可能为评估新治疗方法的疗效提供一种高度敏感的技术。
Diffusion-weighted imaging (DWI) is a new magnetic resonance imaging technique that detects the tiny random movements of water molecules (diffusion) in tissues. This technique allows a map of the average apparent diffusion coefficient (ADC) to be calculated. Shot-try after the onset of an ischemic stroke, the ADC of brain tissue is significantly reduced because of cytotoxic edema. Over several days, the rapid initial drop in ADC is followed by a return to "pseudonormal" values at approximately 1 week. Subsequently, elevated ADC values are seen at chronic time points. DWI is remarkably sensitive in detecting and localizing acute ischemic brain lesions and allows differentiation of acute regions of ischemia from chronic infarcts. Recent studies have shown a high correlation between the volume of early DWI lesions and clinical neurologic outcome. In addition, the volume of the early DWI lesion correlates well with final infarct volume as measured by T2-weighted imaging. Therefore, this technique may facilitate optimal selection of patients for new medical therapies for stroke and may provide a highly sensitive technique for evaluating the efficacy of new treatments.