Plasma 25-hydroxyvitamin D and its determinants in an elderly population sample
Plasma 25-hydroxyvitamin D and its determinants in an elderly population sample
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DOI：
10.1093/ajcn/66.4.929
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发表时间：
1997-10-01
影响因子：
7.1
通讯作者：
Rush, D
中科院分区：
文献类型：
--
作者：
Jacques, PF;Felson, DT;Rush, D
本研究描述了 Framingham 心脏研究队列中年龄 67-95 岁的 290 名男性和 469 名女性血浆 25-羟基维生素 D [25(OH)D] 浓度的分布和决定因素以及低 25(OH)D（小于或等于 37.5 nmol/L）的危险因素。男性平均 (+/- SD) 25(OH)D 浓度为 82 +/- 29 nmol/L，女性为 71 +/- 29 nmol/L。 6.2% 的男性和 14.5% 的女性 25(OH)D 较低。 25(OH)D 浓度与检查季节密切相关，与室内时间和体重指数呈负相关，与膳食维生素 D 摄入量呈正相关。在女性中，浓度也与年龄呈负相关，与补充维生素 D 摄入量以及在佛罗里达州、加利福尼亚州或亚利桑那州居住时间大于或等于 3 个月/年呈正相关，而在男性中，浓度与血清肌酐浓度呈正相关。维生素 D 摄入量和阳光照射可以解释 25(OH)D 浓度的类似差异，前者对女性更重要，后者对男性更重要。已知或怀疑的维生素 D 状态决定因素均无法解释女性体内较低的 25(OH)D 浓度，但在冬季检查的个体中未发现性别差异。这项基于人口的老年人样本的结果表明，维生素 D 状况不足是一个重要的公共卫生问题，可以通过摄入足够的维生素 D 或接触阳光来轻松解决这一问题。
This study describes the distribution and determinants of plasma 25-hydroxyvitamin D [25(OH)D] concentrations and risk factors for low 25(OH)D (less than or equal to 37.5 nmol/L) in 290 men and 469 women aged 67-95 y who were in the Framingham Heart Study cohort. Mean (+/- SD) 25(OH)D concentrations were 82 +/- 29 nmol/L in men and 71 +/- 29 nmol/L in women. 25(OH)D was low in 6.2% of men and 14.5% of women. 25(OH)D concentrations were strongly associated with season of examination, inversely associated with time spent indoors and body mass index, and positively associated with dietary vitamin D intake. In women, concentrations were also inversely associated with age and positively associated with supplemental vitamin D intake and residence for greater than or equal to 3 mo/y in Florida, California, or Arizona, and in men were positively associated with serum creatinine concentrations. Similar amounts of variance in 25(OH)D concentrations were explained by vitamin D intake and sunlight exposure, the former being more important in women and the latter in men. None of the known or suspected determinants of vitamin D status could explain the lower 25(OH)D concentrations in women, but the sex difference was not seen for individuals examined during the winter. Results from this population-based sample of elderly individuals suggest that inadequate vitamin D status is an important public health problem, which could be readily addressed by adequate vitamin D intake or sunlight exposure.