Dressed to impress: impact of environmental adaptation on the Candida albicans cell wall.
Dressed to impress: impact of environmental adaptation on the Candida albicans cell wall.
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DOI：
10.1111/mmi.13020
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发表时间：
2015-07
影响因子：
3.6
通讯作者：
Hall RA
中科院分区：
文献类型：
--
作者：
Hall RA
白色念珠菌是一种人类机会性真菌病原体，可引起浅表粘膜感染和危及生命的全身性疾病。真菌细胞壁是入侵病原体与宿主先天免疫系统之间的第一个接触点。因此，构成细胞壁的多糖充当病原体相关的分子模式，其控制宿主-病原体相互作用。细胞壁是动态的，并对外部环境的变化做出反应。因此，宿主环境通过调节真菌细胞壁在调节宿主-病原体相互作用中起关键作用。本文综述了环境适应如何调节白念珠菌细胞壁的结构和组成，以及对白念珠菌先天免疫识别的影响。
C andida albicans is an opportunistic fungal pathogen of humans causing superficial mucosal infections and life‐threatening systemic disease. The fungal cell wall is the first point of contact between the invading pathogen and the host innate immune system. As a result, the polysaccharides that comprise the cell wall act as pathogen associated molecular patterns, which govern the host–pathogen interaction. The cell wall is dynamic and responsive to changes in the external environment. Therefore, the host environment plays a critical role in regulating the host–pathogen interaction through modulation of the fungal cell wall. This review focuses on how environmental adaptation modulates the cell wall structure and composition, and the subsequent impact this has on the innate immune recognition of C . albicans.