CELLULAR SENSITIVITY TO COLLAGEN IN RHEUMATOID-ARTHRITIS
CELLULAR SENSITIVITY TO COLLAGEN IN RHEUMATOID-ARTHRITIS
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DOI：
10.1056/nejm197808172990703
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发表时间：
1978-01-01
影响因子：
158.5
通讯作者：
DAVID, JR
中科院分区：
文献类型：
--
作者：
TRENTHAM, DE;DYNESIUS, RA;DAVID, JR
类风湿性关节炎患者的细胞敏感性进行了检查，以天然的人I型，II型和III型胶原蛋白。对50例类风湿性关节炎患者、21例其他炎性关节炎患者、20例骨关节炎患者和20例正常受试者的单核细胞进行了评价，以确定白细胞抑制因子对胶原蛋白和对照抗原链激酶-链道酶的体外反应。通过这种测定，分别有37例（74%）和39例（78%）类风湿性关节炎患者的细胞对II型和III型胶原蛋白有反应。来自41名其他类型关节炎患者和正常组的细胞不产生这种胶原蛋白淋巴因子。对I型胶原或变性α-胶原没有反应。这些胶原蛋白链。所有4组对链激酶-链道酶的反应均相等。大多数类风湿性关节炎患者对II型和III型胶原蛋白表现出细胞敏感性。
Patients with rheumatoid arthritis were examined for cellular sensitivity to native human types I, II and III collagens. Mononuclear cells from 50 patients with rheumatoid arthritis, 21 with other inflammatory arthritides, 20 with osteoarthritis and 20 normal subjects were evaluated for the in vitro production of leukocyte inhibitory factor in response to collagen and a control antigen, streptokinase-streptodornase. By this assay, cells from 37 (74%) and 39 (78%) of the patients with rheumatoid arthritis responded to types II and III collagens, respectively. Cells from the 41 patients with other kinds of arthritis and the normal group did not produce this lymphokine to collagens. There was no response to type I collagen or to denatured .alpha.-chains of these collagens. All 4 groups responded equivalently to streptokinase-streptodornase. Most patients with rheumatoid arthritis exhibit cellular sensitivity to types II and III collagens.