Boosting of Secretory IgA Antibody Responses in Man by Parenteral Cholera Vaccination
Boosting of Secretory IgA Antibody Responses in Man by Parenteral Cholera Vaccination
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肠外霍乱疫苗接种增强人类分泌型 IgA 抗体反应
DOI：
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发表时间：
1977
影响因子：
3.7
通讯作者：
R. Rahimtoola
中科院分区：
文献类型：
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作者：
A. Svennerholm;J. Holmgren;L. Hanson;B. Lindblad;F. Quereshi;R. Rahimtoola
在一个非常低的社会经济群体的巴基斯坦妇女的血清，牛奶和唾液中的特异性抗体霍乱弧菌脂多糖的发生进行了研究之前和之后，一个单一的皮下霍乱疫苗接种。在免疫接种前，所有妇女血清中特异性抗体水平较低，主要是IgM类抗体，在许多情况下，在牛奶和唾液中也发现了霍乱伊加抗体，这表明自然接触较早。疫苗接种持续诱导血清抗体滴度显著升高，并且在70%的乳汁和45%的唾液样品中也显著增加了滴度。而诱导的血清抗体主要是IgG类，分泌型伊加负责大部分滴度增加的分泌物。结果表明，肠外霍乱疫苗接种可以提高局部分泌型伊加抗体反应在肠道致敏的个人。
The occurrence of specific antibodies to Vibrio cholerae lipopolysaccharide in serum, milk, and saliva of Pakistani women from a very low socioeconomic group was studied before and after a single subcutaneous cholera vaccination. Before immunization all women had low levels of specific antibodies in serum, primarily of IgM class, and in many cases cholera IgA antibodies were found in milk and saliva as well, indicating earlier natural exposure. The vaccination consistently induced a marked rise in serum antibody titer, and notably also produced significant titer increases in 70% of the milk and in 45% of the saliva samples. Whereas the serum antibodies induced were predominantly of the IgG class, secretory IgA was responsible for most of the titer increase in the secretions. The results indicate that parenteral cholera vaccination can boost local secretory IgA antibody responses in intestinally primed individuals.