Impact of metabolic complications on antiretroviral treatment adherence: clinical and public health implications.
Impact of metabolic complications on antiretroviral treatment adherence: clinical and public health implications.
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DOI：
10.1007/s11904-009-0017-9
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发表时间：
2009-08-01
影响因子：
4.6
通讯作者：
Ammassari, Adriana
中科院分区：
文献类型：
--
作者：
Nachega, Jean B;Trotta, Maria Paola;Ammassari, Adriana
抗逆转录病毒治疗（ART）是预防HIV感染疾病进展的有效策略，特别是当患者密切遵守治疗方案时。然而，ART药物可能会引起副作用，包括可能影响患者依从性水平的代谢并发症。与ART相关的选定慢性并发症包括脂肪代谢障碍、高脂血症、胰岛素抵抗和糖尿病、周围神经病变和骨疾病如骨质减少/骨质疏松症。在这篇文章中，我们回顾了这些代谢并发症对ART依从性的影响以及预防或逆转这些并发症的方法。
Antiretroviral therapy (ART) is an effective strategy for preventing disease progression of HIV infection, particularly when patients adhere closely to the treatment regimen. However, ART medications can cause side effects, including metabolic complications that can impact patients' adherence levels. Selected chronic complications associated with ART include lipodystrophy, hyperlipidemia, insulin resistance and diabetes, peripheral neuropathy, and bone disorders such as osteopenia/osteoporosis. In this article, we review the effects of these metabolic complications on ART adherence and approaches to prevent or reverse them.