Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease.
Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease.
复制标题
DOI：
10.3389/fnana.2016.00077
复制
发表时间：
2016
影响因子：
2.9
通讯作者：
Hallböök F
中科院分区：
文献类型：
--
作者：
Boije H;Shirazi Fard S;Edqvist PH;Hallböök F
对神经元群体的彻底调查可以帮助揭示关于神经系统及其发育的关键方面。视网膜水平细胞有几个非凡的功能，使他们特别感兴趣的解决有关命运分配和亚型规范的问题。在这篇综述中，我们讨论和总结有关水平细胞的形成和多样性的数据，形态学是如何与分子标记，以及命运分配如何将水平谱系与其他视网膜细胞类型的谱系分开。我们讨论了水平祖细胞的最后细胞周期的新的和独特的功能，以及它们如何可能与视网膜母细胞瘤癌变。
Thorough investigation of a neuronal population can help reveal key aspects regarding the nervous system and its development. The retinal horizontal cells have several extraordinary features making them particularly interesting for addressing questions regarding fate assignment and subtype specification. In this review we discuss and summarize data concerning the formation and diversity of horizontal cells, how morphology is correlated to molecular markers, and how fate assignment separates the horizontal lineage from the lineages of other retinal cell types. We discuss the novel and unique features of the final cell cycle of horizontal cell progenitors and how they may relate to retinoblastoma carcinogenesis.