Role of Striatum in Updating Values of Chosen Actions
Role of Striatum in Updating Values of Chosen Actions
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DOI：
10.1523/jneurosci.2728-09.2009
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发表时间：
2009-11-25
影响因子：
5.3
通讯作者：
Jung, Min Whan
中科院分区：
文献类型：
--
作者：
Kim, Hoseok;Sul, Jung Hoon;Jung, Min Whan
纹状体被认为在基于价值的决策中起着至关重要的作用。虽然大量的证据表明它参与了动作选择和动作评价，但纹状体这些功能的潜在神经过程在很大程度上是未知的。为了深入了解这一问题，我们同时记录了神经元活动的背侧和腹侧纹状体的大鼠执行动态双臂强盗任务，并检查时间轮廓的神经信号相关的动物的选择，其结果，和行动价值。而显着的神经信号的行动价值被发现在这两个结构之前，动物的选择的行动，即将到来的选择相关的信号相对较弱，并开始出现在背侧纹状体类似的200毫秒前的行为表现的动物的选择。与此相反，一旦动物揭示了它的选择，与选择及其价值相关的信号急剧增加，并持续到动物选择的结果被揭示，因此两种结构中的一些神经元同时传递与动物选择，其结果以及所选择行为的价值相关的信号。因此，所有必要的组件更新所选择的行动的价值观可在纹状体。这些结果表明，纹状体不仅代表与动物的行动选择之前的潜在选择相关的价值，但一旦其结果被揭示，也可能更新所选择的行动的价值。相比之下，行为选择可能发生在其他地方，或者只在行为表现之前的瞬间发生在背侧纹状体。
The striatum is thought to play a crucial role in value-based decision making. Although a large body of evidence suggests its involvement in action selection as well as action evaluation, underlying neural processes for these functions of the striatum are largely unknown. To obtain insights on this matter, we simultaneously recorded neuronal activity in the dorsal and ventral striatum of rats performing a dynamic two-armed bandit task, and examined temporal profiles of neural signals related to animal's choice, its outcome, and action value. Whereas significant neural signals for action value were found in both structures before animal's choice of action, signals related to the upcoming choice were relatively weak and began to emerge only in the dorsal striatum similar to 200 ms before the behavioral manifestation of the animal's choice. In contrast, once the animal revealed its choice, signals related to choice and its value increased steeply and persisted until the outcome of animal's choice was revealed, so that some neurons in both structures concurrently conveyed signals related to animal's choice, its outcome, and the value of chosen action. Thus, all the components necessary for updating values of chosen actions were available in the striatum. These results suggest that the striatum not only represents values associated with potential choices before animal's choice of action, but might also update the value of chosen action once its outcome is revealed. In contrast, action selection might take place elsewhere or in the dorsal striatum only immediately before its behavioral manifestation.