Demographic, health, lifestyle, and blood vitamin determinants of serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey, 1988-1994
Demographic, health, lifestyle, and blood vitamin determinants of serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey, 1988-1994
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DOI：
10.1093/ajcn/77.4.826
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发表时间：
2003-04-01
影响因子：
7.1
通讯作者：
Kafai, MR
中科院分区：
文献类型：
--
作者：
Ganji, V;Kafai, MR
背景：血清总同型半胱氨酸(THcy)升高是血管疾病的一个独立危险因素。目的：研究血清tHcy与人口学、健康和生活方式因素以及血液维生素浓度之间的关系。设计：利用1988-1994年第三次全国健康与营养检查调查的数据，检验男性(n=2965)和女性(n=3580)tHcy与年龄、性别、种族、体重指数、收缩压和舒张压、饮酒、服用补充剂、红细胞叶酸、血清肌酐、叶酸、维生素B-12、结果：未调整的tHcy均值男性比女性高21.5%(约1.9 Mumol/L)，非西班牙裔白人比墨西哥裔美国人高11.8%(约1.1 Mumol/L)，大于或等于70岁者比年龄及年龄组高42%(约3.7 Mumol/L)；30年，补充组比补充组高10.9%(接近1.0mumol/L)。THcy浓度与血清叶酸(P<；趋势为0.0001)、红细胞叶酸(P<；趋势为0.0001)、血清维生素B-12(P<；趋势为0.0036)呈负相关，与饮酒量(P<；趋势为0.0001)、血清可替宁(P<；趋势为0.0001)、收缩压(P<；0.0001，趋势为P<；)呈正相关。烈性酒(而不是啤酒或葡萄酒)的消费量与tHcy浓度呈正相关(趋势P<；0.0001)。结论：在这项以人群为基础的研究中，tHcy浓度的显著预测因素是性别、年龄、种族、血肌酐、收缩压、体重指数、烈性酒消费量、吸烟、补充剂使用、血清叶酸、红细胞叶酸和血清维生素B-12。
Background: Elevated serum total homocysteine (tHcy) is an independent risk factor for vascular diseases.Objective: Associations between serum tHcy and demographics, health and lifestyle factors, and blood vitamin concentrations were investigated.Design: Data from the third National Health and Nutrition Examination Survey, 1988-1994 were used to examine associations in men (n = 2965) and women (n = 3580) between tHcy and age, sex, race-ethnicity, body mass index, systolic and diastolic blood pressures, alcohol consumption, supplement use, red blood cell (RBC) folate, and serum creatinine, folate, vitamin B-12, and cotinine (a measure of cigarette smoking).Results: The unadjusted mean tHcy was 21.5% (approximate to1.9 mumol/L) higher in men than in women, 11.8% ( approximate to1.1 mumol/L) higher in non-Hispanic whites than in Mexican Americans, 42% ( approximate to3.7 mumol/L) higher in persons aged greater than or equal to70 y than in persons aged < 30 y, and 10.9% (approximate to1.0 mumol/L) higher in supplement nonusers than in supplement users. The tHcy concentration was negatively associated with serum folate (P < 0.0001 for trend), RBC folate (P < 0.0001 for trend), and serum vitamin B-12 (P < 0.0036 for trend) and was positively associated with alcohol consumption (P < 0.0001 for trend), serum cotinine (P < 0.0001 for trend), and systolic blood pressure (P < 0.0001 for trend). Consumption of hard liquor (but not of beer or wine) was positively associated with tHcy concentration (P < 0.0001 for trend).Conclusions: In this population-based study, the significant predictors of tHcy concentration were sex, age, race-ethnicity, serum creatinine, systolic blood pressure, body mass index, hard-liquor consumption, smoking, supplement use, serum folate, RBC folate, and serum vitamin B-12.