Sucralose Suppresses Food Intake.
Sucralose Suppresses Food Intake.
复制标题
三氯蔗糖抑制食物摄入。
DOI：
10.1016/j.cmet.2017.02.011
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发表时间：
2017
期刊：
影响因子：
29
通讯作者：
Ja,WilliamW
中科院分区：
文献类型：
--
作者：
Park,JinHong;Carvalho,GilB;Murphy,KeithR;Ehrlich,MargauxR;Ja,WilliamW
Despite their widespread use, non-nutritive sweeteners (NNSs) have remained controversial due to their potential impact on body weight, metabolism, and energy homeostasis (Burke and Small, 2015). In a recent paper in Cell Metabolism, Wang et al.(2016) tested the effect of the NNS sucralose on feeding behavior in Drosophila. Their experimental paradigm consisted of an Exposure Phase (of up to 6 days) on sucralose-laced food, followed by a trial period on regular, sucralose-free diet (Figure S1A). The authors show that animals exposed to sucralose subsequently overeat when switched to sucralose-free food. Wang et al.(2016) interpret this observation by suggesting that prolonged sucralose ingestion triggers a neuronal response that simulates a fasting state and promotes food intake. An untested alternative hypothesis is that flies alter their consumption of sucraloselaced food during the Exposure Phase, thereby affecting nutrient intake and potentially influencing all subsequent feeding behavior. Here, we show that flies indeed change their intake of sucralosecontaining food, supporting the latter hypothesis.Using radiolabeled fly food identical in composition to that used by Wang et al.(2016), we found that flies ate less when the medium contained sucralose. This effect was seen on the first day (8% decrease relative to control) and, to a greater extent, on the sixth day (16% decrease relative to control) of sucralose exposure (Figure S1B). We confirmed the impact of sucralose on consumption using the capillary feeder (CAFE) assay, which directly measures the volume of liquid food consumed (Ja et al., 2007). Consistent with the radiolabeled food results, sucralose decreased total consumption (Figure S1C). Consumption was also sup-
