Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke
Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke
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DOI：
10.1161/01.str.0000046764.57344.31
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发表时间：
2003-01-01
期刊：
影响因子：
8.3
通讯作者：
Dávalos, A
中科院分区：
文献类型：
--
作者：
Castellanos, M;Leira, R;Dávalos, A
背景和目的-基质金属蛋白酶-9（MMP-9）活性与脑缺血实验模型中的出血性转化（HT）有关。我们的目的是调查MMP-9浓度之间的关系在24小时内中风发作和随后HT的cerebralinfarct. Methods，我们研究了250例患者的半球缺血性中风的7.8+/-4.5小时的持续时间。入院时评估脑梗死的早期CT征象。HT和梗死体积从第4天至第7天进行的CT分析。MMP-9水平测定酶联免疫吸附试验在血液样本中获得的admission.Results-HT观察到38例（15.2%）：24（63.2%）有出血性梗死，和14（36.8%）有实质性血肿。共有108名患者（43%）在第二次CT扫描前接受抗凝剂治疗。HT组的收缩压和舒张压、体温、早期缺血CT征象的频率（92%对22%）和抗凝治疗（79%对37%）显著高于HT组（P
Background and Purpose-Matrix metalloproteinase-9 (MMP-9) activity has been associated with hemorrhagic transformation (HT) in experimental models of cerebral ischemia. Our aim was to investigate the relationship between MMP-9 concentrations in blood within 24 hours of stroke onset and subsequent HT of cerebral infarction.Methods-We studied 250 patients with a hemispheric ischemic stroke of 7.8+/-4.5 hours' duration. Early CT signs of cerebral infarction were evaluated on admission. The HT and infarct volume were analyzed from the CT performed on days 4 through 7. MMP-9 levels were determined by enzyme-linked immunosorbent assay in blood samples obtained on admission.Results-HT was observed in 38 patients (15.2%): 24 (63.2%) had a hemorrhagic infarction, and 14 (36.8%) had a parenchymal hematoma. A total of 108 patients (43%) received anticoagulants before the second CT scan. Systolic and diastolic blood pressures, body temperature, frequency of early CT signs of ischemia (92% versus 22%), and treatment with anticoagulants (79% versus 37%) were significantly higher in the group with HT (P