Contrast and luminance adaptation alter neuronal coding and perception of stimulus orientation
Contrast and luminance adaptation alter neuronal coding and perception of stimulus orientation
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DOI：
10.1038/s41467-019-08894-8
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发表时间：
2019-02-26
影响因子：
16.6
通讯作者：
Price，Nicholas S. C.
中科院分区：
文献类型：
--
作者：
Ghodrati，Masoud;Zavitz，Elizabeth;Price，Nicholas S. C.
感觉系统面临着一连串的刺激，这些刺激沿着沿着多个维度不断变化。这些同时发生的变化给神经系统带来了一个棘手的问题，因为神经元必须动态地对每个刺激维度进行编码，而不管其他维度的变化。在这里，我们测量了视觉皮层中的神经元如何在亮度和对比度的变化后编码方向，这对视觉处理至关重要，但在方向编码的背景下是讨厌的变量。使用信息论分析和人口解码的方法，我们发现，方向的可辨别性是亮度和对比度依赖，随着时间的推移，由于放电率适应。我们还表明，在人类观察员的方向歧视的变化，在适应过程中，与神经元数据一致的方式。我们的研究结果表明，适应本身并不保持信息速率，而是采取行动，以保持感官系统的运作在有限的动态范围内提供的尖峰活动，尽管范围广泛的可能的输入。
Sensory systems face a barrage of stimulation that continually changes along multiple dimensions. These simultaneous changes create a formidable problem for the nervous system, as neurons must dynamically encode each stimulus dimension, despite changes in other dimensions. Here, we measured how neurons in visual cortex encode orientation following changes in luminance and contrast, which are critical for visual processing, but nuisance variables in the context of orientation coding. Using information theoretic analysis and population decoding approaches, we find that orientation discriminability is luminance and contrast dependent, changing over time due to firing rate adaptation. We also show that orientation discrimination in human observers changes during adaptation, in a manner consistent with the neuronal data. Our results suggest that adaptation does not maintain information rates per se, but instead acts to keep sensory systems operating within the limited dynamic range afforded by spiking activity, despite a wide range of possible inputs.