Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks
Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks
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DOI：
10.1016/j.brainres.2005.05.035
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发表时间：
2005-07-19
期刊：
影响因子：
2.9
通讯作者：
Furuse, M
中科院分区：
文献类型：
--
作者：
Tachibana, T;Sato, M;Furuse, M
含有C-末端Arg-Phe-NH 2基序的神经肽（RFamide肽）被认为参与无脊椎动物和脊椎动物的摄食行为控制。促性腺激素抑制激素（GnIH）是第一个被鉴定的抑制垂体促性腺激素释放的禽类RF酰胺肽。GnIH前体编码一种GnIH及其相关肽（GnIH-RP-1和-RP-2），它们具有相同的C-末端基序Leu-Pro-Xaa-Arg-Phe-NH 2（Xaa = Leu或Gln）（LPXRF酰胺）。GnIH神经元位于室旁核，其纤维可见于多个大脑位置，包括正中隆起和脑干。因此，在这项研究中，我们研究了GnIH及其相关肽对摄食行为的作用。脑室内（ICV）注射GnIH、GnIH-RP-1和GnIH-RP-2显着刺激小鸡的摄食量。鸡五肽LPLRF酰胺（GnIH和GnIH-RP-1的降解C-末端）不刺激进食，从而证明了GnIH及其相关肽的N-末端对食欲促进作用的重要性。抗GnIH抗血清抑制禁食诱导的食欲，但不改变自由采食条件下的喂养。提示GnIH及其相关肽在鸡脑中起内源性促食欲因子的作用。(C)2005 Elsevier B. V.保留所有权利。
Neuropeptides containing a C-terminal Arg-Phe-NH2 motif (RFamide peptides) are suggested to be involved in the control of feeding behavior in both invertebrates and vertebrates. Gonadotropin-inhibitory hormone (GnIH) is the first identified avian RFamide peptide that inhibits gonadotropin release from the pituitary. The GnIH precursor encodes one GnIH and its related peptides (GnIH-RP-1 and -RP-2) that shared the same C-terminal motif, Leu-Pro-Xaa-Arg-Phe-NH2 (Xaa = Leu or Gin) (LPXRFamide). GnIH neurons are localized in the paraventricular nucleus, with their fibers visible in multiple brain locations including the median eminence and brainstem. In this study, we therefore investigated the action of GnIH and its related peptides on feeding behavior. Intracerebroventricular (ICV) injection of GnIH, GnIH-RP-1 and GnIH-RP-2 significantly stimulated food intake in chicks. The chicken pentapeptide LPLRFamide, a degraded C-terminus of GnIH and GnIH-RP-1, did not stimulate feeding thereby demonstrating the importance of the N-terminus of GnIH and its related peptides for the orexigenic effect. Anti-GnIH antiserum suppressed appetite induced by fasting, but did not modify feeding under ad libitum conditions. The present study suggests that GnIH and its related peptides act as endogenous orexigenic factors in the brain of chicks. (C) 2005 Elsevier B.V. All rights reserved.