DDQ-mediated Direct C(sp3)H Cyanation of Benzyl Ethers and 1,3-Diarylpropenes under Solvent- and Metal-free Conditions
DDQ-mediated Direct C(sp3)H Cyanation of Benzyl Ethers and 1,3-Diarylpropenes under Solvent- and Metal-free Conditions
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DOI：
10.1002/adsc.201500096
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发表时间：
2015-08
影响因子：
5.4
通讯作者：
Shanshan Kong;Lingqiong Zhang;Xiaoli Dai;Lianzhi Tao;Chunsong Xie;Lei Shi;Min Wang
中科院分区：
文献类型：
--
作者：
Shanshan Kong;Lingqiong Zhang;Xiaoli Dai;Lianzhi Tao;Chunsong Xie;Lei Shi;Min Wang
在无溶剂和无金属的条件下，用TMSCN直接氰化苯醚和1,3 -二烷基丙烯。这种氧化交叉脱水偶联（CDC）反应是由2,3‐二氯‐5,6‐二氰‐1,4‐苯醌（DDQ）促进的，可以快速获得多种腈，收率很高。
A direct cyanation of benzyl ethers and 1,3‐diarylpropenes with TMSCN was performed under solvent‐ and metal‐free conditions. This oxidative cross dehydrative coupling (CDC) reaction was promoted by 2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ) and provided rapid access to a broad range of nitriles in good to excellent yields.