Adverse pregnancy outcomes in snuff users
Adverse pregnancy outcomes in snuff users
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DOI：
10.1067/s0002-9378(03)00661-6
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发表时间：
2003-10-01
影响因子：
9.8
通讯作者：
Cnattingius, S
中科院分区：
文献类型：
--
作者：
England, LJ;Levine, RJ;Cnattingius, S
目的：这项研究的目的是评估无烟烟草使用在pregnancy.Study设计的影响：我们研究了出生体重，早产，先兆子痫的妇女谁交付的单胎，活产婴儿在瑞典从1999年至2000年。结果：排除后，鼻烟使用者789人，吸烟者11,240人，非吸烟者11,495人。与非使用者相比，鼻烟使用者校正的平均出生体重减少39 g（95%CI，6-72 g），吸烟者减少190 g（95%CI，178-202 g）。鼻烟使用者和吸烟者的早产率增加（调整后的比值比分别为1.98 [95%CI，1.46-2.68]和1.57 [95%CI，1.38-1.80]）。吸烟者的先兆子痫发生率降低（校正比值比，0.63; 95%CI，0.53-0.75），但鼻烟使用者的先兆子痫发生率升高（校正比值比，1.58; 95%CI，1.09-2.27）。结论：鼻烟使用与早产和先兆子痫的风险增加有关。在怀孕期间，鼻烟似乎不是香烟的安全替代品。
OBJECTIVE: The purpose of the study was to evaluate the effects of smokeless tobacco use during pregnancy.STUDY DESIGN: We examined birth weight, preterm delivery, and preeclampsia in women who were delivered of singleton, live-born infants in Sweden from 1999 through 2000. For each snuff user, 10 cigarette smokers and 10 tobacco nonusers were selected randomly.RESULTS: After exclusions, 789 snuff users, 11,240 smokers, and 11,495 nonusers remained. Compared with nonusers, adjusted mean birth weight was reduced in snuff users by 39 g (95% Cl, 6-72 g) and in smokers by 190 g (95% Cl, 178-202 g). Preterm delivery was increased in snuff users and smokers (adjusted odds ratios, 1.98 [95% Cl, 1.46-2.68] and 1.57 [95% Cl, 1.38-1.80], respectively). Preeclampsia was reduced in smokers (adjusted odds ratio, 0.63; 95% Cl, 0.53-0.75) but increased in snuff users (adjusted odds ratio, 1.58; 95% Cl, 1.09-2.27).CONCLUSION: Snuff use was associated with increased risk of preterm delivery and preeclampsia. Snuff does not appear to be a safe alternative to cigarettes during pregnancy.