Sympathetic nervous system in age-related cardiovascular dysfunction: Pathophysiology and therapeutic perspective
Sympathetic nervous system in age-related cardiovascular dysfunction: Pathophysiology and therapeutic perspective
复制标题
交感神经系统与年龄相关性心血管功能障碍的病理生理学及治疗前景
DOI：
10.1016/j.biocel.2019.01.004
复制
发表时间：
2019-03-01
影响因子：
4
通讯作者：
Koch, Walter J.
中科院分区：
文献类型：
--
作者：
de Lucia, Claudio;Piedepalumbo, Michela;Koch, Walter J.
心力衰竭和代谢综合征等心血管疾病在老年人群中的患病率很高，是导致死亡、残疾、住院的主要原因，在全球范围内推动了高昂的医疗保健成本。为了减轻这种社会和经济负担，迫切需要找到有效的治疗靶点。一些研究已经将交感神经系统和β-肾上腺素能受体信号传导的功能障碍与年龄相关的心血管疾病的发病机制联系起来。已证明恢复其功能的治疗性治疗对心血管合并症受试者有效。事实上，生活方式干预（如运动训练和饮食）以及药物治疗（如β受体阻滞剂或莫索尼定）和微创干预（肾交感神经去神经）对年龄相关的心血管疾病有有益的影响。在当前的“焦点医学”文章中，我们将讨论交感神经系统在年龄相关性心血管疾病中的致病作用以及当前和新的治疗方法。
Cardiovascular diseases such as heart failure and metabolic syndrome have high prevalence in the elderly population and are leading causes of death, disability, hospitalization, driving high healthcare costs worldwide. To reduce this social and economic burden there is urgency to find effective therapeutic targets. Several studies have linked the dysfunction of the Sympathetic Nervous System and beta-adrenergic receptor signaling with the pathogenesis of age-related cardiovascular diseases. Therapeutic treatments that restore their functions have been shown to be effective in subjects with cardiovascular comorbidities. In fact, lifestyle interventions (such as exercise training and diet) as well as pharmacologic treatments (e.g. beta-blockers or moxonidine) and mini-invasive interventions (renal sympathetic denervation) have beneficial effects on age-related cardiovascular diseases. In the current "Medicine in focus" article we will discuss the pathogenic role of the Sympathetic Nervous System in age-related cardiovascular diseases as well as current and new therapeutic approaches.