Glucocorticoid-induced down regulation of transforming growth factor-beta 1 in adult rat lung fibroblasts.
Glucocorticoid-induced down regulation of transforming growth factor-beta 1 in adult rat lung fibroblasts.
复制标题
糖皮质激素诱导成年大鼠肺成纤维细胞转化生长因子-β1 的下调。
作者：
Shull,S;Meisler,N;Absher,M;Phan,S;Cutroneo,K
正常成年大鼠肺成纤维细胞经地塞米松处理后，转化生长因子-β1m RNA和转化生长因子β活性降低。地塞米松在2小时内引起转化生长因子-β1mRNA的表达下降，且持续时间至少超过24小时。转化生长因子-β-1m RNA表达的降低与剂量相关。水貂肺成纤维细胞生长抑制实验显示，地塞米松处理组大鼠肺成纤维细胞转化生长因子β活性降低。这些数据表明，糖皮质激素可能至少部分地通过介导转化生长因子-β1调节大鼠肺成纤维细胞的胶原合成。
Transforming growth factor-β1 mRNA and transforming growth factor β activity are decreased with exposure of normal adult rat lung fibroblasts to dexamethasone. Dexamethasone caused a decrease in transforming growth factor-β1 mRNA within 2 hours, which was sustained at least over a 24-hour period. The decrease in transforming growth factor-β1 mRNA was dose related. Dexamethasone treatment of rat lung fibroblasts also resulted in a decrease of transforming growth factor β activity as determined by the mink lung cell growth inhibition assay. These data indicate that glucocorticoids may regulate collagen synthesis at least in part through the mediation of transforming growth factor-β1 in rat lung fibroblasts.