Cleft lip, nose, and palate: the nasal septum as the pacemaker for midfacial growth
Cleft lip, nose, and palate: the nasal septum as the pacemaker for midfacial growth
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DOI：
10.1016/j.oooo.2012.05.005
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发表时间：
2013-04-01
影响因子：
2.9
通讯作者：
Precious, David S.
中科院分区：
文献类型：
--
作者：
Hall, Brian K.;Precious, David S.
外科医生在试图矫正颅面缺损（如单侧或双侧唇裂/腭裂或创伤后面中部损伤）时，需要了解软骨发育和生长的动态。在颅面区域内，鼻中隔软骨和蝶筛和蝶枕颅软骨结合与其他颅面软骨不同，具有内在的生长潜力。事实上，鼻中隔软骨的生长超过了面中部其他骨骼和软组织的生长，以至于它是面部和颅骨前部生长的起搏器。我们重新审视并加强了鼻中隔作为起搏器的重要性，分析了3类证据：非人类哺乳动物模型中鼻中隔的体内生长;鼻中隔软骨或软骨细胞的组成和体外生长;单侧或双侧面裂的手术修复经验。(Oral外科口腔医学口腔病理学口腔放射学2013;115：442-447）
The need to be aware of the dynamics of cartilage development and growth is encountered by surgeons whenever they attempt to correct craniofacial defects such as unilateral or bilateral cleft lip/cleft palate or midfacial injuries after trauma. Within the craniofacial region, the nasal septal cartilage and the sphenoethmoidal and sphenooccipital cranial synchondroses are distinguished from other craniofacial cartilages in possessing intrinsic growth potential. Indeed, growth of the nasal septal cartilage outstrips the growth of other skeletal and soft tissues in the midface to such an extent that it is the pacemaker for growth of the face and anterior portion of the skull. We revisit and reinforce the importance of the nasal septum as pacemaker with analysis of 3 classes of evidence: in vivo growth of the nasal septum in nonhuman mammalian models; composition and in vitro growth of nasal septal cartilage or chondrocytes; and experience from the surgical repair of unilateral or bilateral facial clefts. (Oral Surg Oral Med Oral Pathol Oral Radiol 2013;115:442-447)